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(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors
Authors:Ha-Soon Choi  Paul V. Rucker  Zhicheng Wang  Yi Fan  Pamela Albaugh  Greg Chopiuk  Francois Gessier  Fangxian Sun  Francisco Adrian  Guoxun Liu  Tami Hood  Nanxin Li  Yong Jia  Jianwei Che  Susan McCormack  Allen Li  Jie Li  Auzon Steffy  AnneMarie Culazzo  Celine Tompkins  Van Phung  Andreas Kreusch  Min Lu  Bin Hu  Apurva Chaudhary  Mahavir Prashad  Tove Tuntland  Bo Liu  Jennifer Harris  H. Martin Seidel  Jon Loren  Valentina Molteni
Affiliation:Genomics Institute of theNovartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States
Abstract:
Keywords:Neurotrophins   tropomyosin receptor kinase   TRK   (R)-2-phenylpyrrolidine   imidazopyridazines   GNF-8625
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