放疗、化疗粒子联合植入法治疗复发性甲状腺癌

目的观察放疗、化疗粒子联合植入法治疗复发性甲状腺癌的疗效。方法选取16例经过放疗治疗和手术后均再次复发的甲状腺癌患者,随机分成观察组与对照组各8例,观察组患者采用放疗、化疗粒子联合植入法进行治疗,在B超引导下将氟尿嘧啶缓释化疗粒子和^125I粒子以交替的方式植入;对照组单纯进行放化疗治疗。观察比较两组临床治疗效果。结果两组均顺利完成治疗计划,未发生任何并发症状及神经损伤或气管损伤。治疗后x线平片检查：观察组所植入的放射粒子的位置均未发生任何变化。治疗后6个月对肿瘤进行CT检查,两组肿瘤体积均在一定程度上有所减小。观察组：完全缓解2例,部分缓解5例,无明显变化1例;对照组：完全缓解1例,部分缓解5例,无明显变化2例;两组临床治疗效果差异有统计学意义（P〈0．05）。随访1年,观察组无1例患者死亡,对照组死亡1例。结论采用放疗、化疗粒子联合植入法治疗复发性甲状腺癌,临床效果好,值得临床推广应用。

Clinical observation of the recurrent thyroid cancer patients treatment with radiotherapy,chemotherapy parficle implantation after targeted therapy

Objective To observe the effect of recurrent thyroid cancer patients treatment with radiotherapy, chemotherapy particle implantation after targeted therapy. Methods 16 thyroid cancer patients after radiotherapy and operation relapsed were seldcted. The patients were randomly divided into the treatment group and the control group, the patients in the treatment group treated with radiotherapy, chemotherapy combined with implantation of targeted for their treatment, through the treatment plan effective vaginal B ultrasound guided, in the 5-FU Sustained-release chemo- therapy particle and a 12si particle in alternating fashion to the implant, the patients of control group treated with che- moradiation therapy. Results 16 patients were all successfully operated. On postoperative patients during the follow- up for half a year, the treatment group adopted CT reexamined patients tumor can be narrowed,which completely in 2 cases, partial remission in 5 patients, 1 patient had no significant changes compared with the control group, the difference was statistically significant ;follow-up of 1 year, prior treatment groups of all patients are in the survival condition,the control group had 1 patient died. Conclusion For recurrent thyroid cancer patients given radiotherapy and chemotherapy, combination with particle implantation targeted treatment, have good effect, which belongs to an effective means of treatment, can be widely used in clinical.