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Inhaled nitric oxide reverses cell-free hemoglobin-induced pulmonary hypertension and decreased lung compliance. Preliminary results |
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| Authors: | Luiz F Poli de Figueiredo Mali Mathru Jaclyn R Jones Daneshvari Solanki George C Kramer |
| Affiliation: | 1. Department of Cardiopneumology, DEX-Instituto do Cora??o, Faculdade do Medicina, Universidade de S?o Paulo, SP, Brazil 2. Department of Anesthesiology, Univ. of Texas Medical Branch, Galveston, TX, USA 3. Department of Pulmonary Care Services, Univ. of Texas Medical Branch, Galveston, TX, USA |
| Abstract: | BackgroundIn order to test the hypothesis that inhaled nitric oxide (NO) reverses the pulmonary hypertension induced by αα-diaspirin crosslinked hemoglobin (ααHb), were studied anesthetized pigs that were administered with a total dose of 200 mg/kg of 10% ααHb. Inhaled NO (5 ppm) was administered for 10 min, and then discontinued for 10 min. This cycle was then repeated with 10 ppm inhaled NO.ResultsααHb caused pulmonary arterial pressure (PAP) to increase from 27 ± 1.7 to 40 ± 3.0 mmHg (P<0.05) and dynamic lung compliance to decrease from 29± 1.5 to 23± 1.6 ml/cmH2O (P < 0.05). After both doses of inhaled NO, but particularly 10 ppm, PAP was reduced (P < 0.05) and lung compliance increased (P < 0.05) from the ααHb levels. When inhaled NO was discontinued PAP again increased and lung compliance decreased to levels significantly different from baseline (P < 0.05).ConclusionWe conclude that cell-free hemoglobin-induced pulmonary hypertension and decreased lung compliance can be selectively counteracted by inhaled NO. |
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