| RP-HPLC法测定生脉注射液中五味子醇甲的含量 |
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| 引用本文： | 张伶,蒋朝阳,咸婧,张涛,宋鑫,唐小海. RP-HPLC法测定生脉注射液中五味子醇甲的含量[J]. 中国药房, 2010, 0(48): 4594-4596 |
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| 作者姓名： | 张伶 蒋朝阳 咸婧 张涛 宋鑫 唐小海 |
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| 作者单位： | [1]成都军区总医院肿瘤诊治中心,成都市610083 [2]重庆莱美药业股份有限公司,重庆市401336 |
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| 基金项目： | 浙江省自然科学基金项目（Y207353）; 浙江省博士后科研项目择优项目（2006-bsh-34） |
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| 摘 要： | 目的:建立生脉注射液中五味子醇甲含量的测定方法。方法:采用反相高效液相色谱(RP-HPLC)法。色谱柱为DikmaO测D浓S度C1(8在135.02～mm64×4m.6g·mLm-(,1r5=μ0m.)99,9流9动,n相=为6)甲范醇围-内水与(6峰5:面35积),积检分测值波线长性为关25系0n良m,好流;速高为、中1.、0低mL浓·度mi的n-加1。样结回果收:五率味为子9醇8.2甲4%的～检100.93%,RSD<2.0%。结论:RP-HPLC法测定五味子醇甲的含量稳定可靠,重复性好,可作为生脉注射液的质量控制方法。
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| 关 键 词： | 五味子醇甲 生脉注射液 反相高效液相色谱法 |
Content Determination of Schizandrin in Shengmai Injection by RP-HPLC |
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| ZHANG Ling,JIANG Chao-yang,XIAN Jing,ZHANG TaoOncology Center,General Hospital of Chengdu Military Command of PLA,Chengdu,China SONG Xin,TANG Xiao-hai. Content Determination of Schizandrin in Shengmai Injection by RP-HPLC[J]. China Pharmacy, 2010, 0(48): 4594-4596 |
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| Authors: | ZHANG Ling JIANG Chao-yang XIAN Jing ZHANG TaoOncology Center General Hospital of Chengdu Military Command of PLA Chengdu China SONG Xin TANG Xiao-hai |
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| Affiliation: | (Chongqing Lummy Pharmaceutical Co.,Ltd.,Chongqing 401336,China) |
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| Abstract: | OBJECTIVE：To establish RP-HPLC method for the content determination of Schizandrin in Shenmai injection.METHODS：The detection was performed on Dikma C18（150 mm×4.6 mm,5 um） column with methanol-water（65：35） as mobile phase at a flow rate of 1.0 mL·min-1 and UV detection wavelength was set at 250 nm.RESULTS：The linear range of schizandrin was 3.2-64 mg·L-1（r=0.999 9,n=6） with recovery of 98.24%-100.93%（RSD2.0%）.CONCLUSION：The method is stable,reliable and reproducible for quality control of Shengmai injection. |
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| Keywords: | Schizandrin Shengmai injection RP-HPLC |
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