A Unique Case of Three Autografts for Acute Myelogenous Leukaemia with Subsequent Long Term Survival in Second Remission |
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Authors: | S. H. Lim A. K. McMillan J. Gribben M. C. Galvin A. H. Goldstone |
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Affiliation: | a Departments of Haematology, University College Hospital, Londonb Pinderfields General Hospital, Wakefield, West Yorkshire |
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Abstract: | We report here a patient with acute mycloid leukaemia who relapsed 20 months after undergoing a double autograft procedure in first remission. He was reinduced and subsequently underwent a third autologous bone marrow transplantation in second remission using bone marrow harvested in second remission and a Busulphan and Cyclophosphamide conditioning regimen. Although the engraftment was very slow, he has remained in second remission for 34+ months. This case demonstrates that durable disease-free survival can be attained by a second preparative therapy, even in second remission, for patients relapsed after autologous bone marrow transplantation. |
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Keywords: | AML durable second remission three ABMT |
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