液基薄层细胞学和组织病理学诊断宫颈病变的对照研究

目的探讨液基薄层细胞学(Thin-Prep-liquid-based cytology test,TCT)筛查宫颈病变的准确性。方法对511例TCT检查标本采用TBS(the bethesda system)诊断系统进行诊断,并对所有病人进行阴道镜下宫颈活检,分析TCT检查结果与病理活检的符合率。结果TCT LSIL以上阳性率为74.36%(380/511),活检阳性率为61.64%(315/511),两者比较有显著性差异(P<0.05)。TCT筛查中LSIL及炎症与宫颈活检的诊断符合率为65.14%(114/175);HSIL及癌变与宫颈活检的诊断符合率为66.67%(146/219),两者比较无显著性差异(P>0.05)。结论TCT是筛查宫颈病变较准确的首选方法,值得推广。

Relativity Analysis of Thin-Prep-liquid-based cytology test and pathologic histology for diagnosis of cervical lesion

Objective To investigate the accuracy of Thin-Prep-liquid-based cytology test for cervical lesion.Methods 511 samples were detected by TCT according to TBS diagnosis system,and all patients were proceeded by cervicalbiopsy under guidance of colposcope. The coincidence of TCT results was statistically compared with the pathological diagnosis.Results The positive rate of lesion up to low-grade squamous intraepithelial lesion (LSIL) was 74.36%(380/511) in TCT,and 61.64%(315/511) in cervicalbiopsy. There was significant difference between them (P<0.05). The coincidence rate of screening cases with LSIL and inflammation was 65.14%(114/175). The coincidence rate of screening cases with high-grade squamous intraepithelial lesion (HSIL) and squamous cell carcinoma was 66.67%(146/219). There was no significant difference between them (P>0.05). Conclusion TCT is the capital method for cervical lesion.