The spatio-temporal pattern of Wallerian degeneration in the Rhesus monkey optic nerve

Summary Three patterns of degeneration were distinguished in the Rhesus monkey optic nerve following eye enucleation. (1) A traumatic zone, extending for 1 to 2 mm from the site of transection and characterized by a rapid infiltration of haematogenous macrophages, the rapid degeneration and removal of all neural elements and the formation of astrocytic scar tissue within 35 days. (2) A conical zone, closely associated with the central retinal blood vessels, in which the pattern of degeneration was similar to the traumatic zone except that the onset was delayed and the removal of debris was slower. There was extensive vesiculation of myelin sheaths in these two zones which was indicative of haematogenous cell infiltration. (3) The remainder of the nerve underwent classical Wallerian degeneration in which endogenous cells slowly phagocytosed the degenerating nerve fibres. These observations are considered relevant to the controversy concerning the identification of the macrophage involved in Wallerian degeneration; many studies have described the macrophage within the area of trauma rather than the macrophage involved at some distance from the site of trauma.Supported by Grants 692-B-2 from the National Multiple Sclerosis Society; NS 02255 and NS 08180 from the National Institutes of Health and a grant from the Alfred P. Sloan Foundation