婴儿肝炎综合征病因探讨

我科于1983年1月～1993年12月，对诊断婴儿（包括新生儿）肝炎综合征的病儿92例，进行尿病毒检测70例，结果人类巨细胞病毒阳性44例，占63％，乙肝病毒阳性5例，单纯疱疹病毒及类冠状病毒各1例，总病毒检出率为72．9％。提示病毒感染，特别是人类巨细胞病毒感染是婴儿肝炎综合征的重要病因。经住院治疗4周。黄疸无明显减退者，应用单光子同位素断层扫描（SPECT）进行肝胆动态显像检查13例，结果11例为胆道闭锁，2例为肝内毛细胆管炎。此13例中尿人类巨细胞病毒（HCMV）阳性11例，提示肝胆管闭锁与人类巨细胞感染有关。

Study on Viral Cause of Hepatitis Syndrome

Urine viruses were detected in 70 eases out of 92 in patient infants (including neonates) with hepatitis syndrome. The result showed human cytomegalovirus positive in 44 cases, HBV in 5 cases, herpes virus in 1 case and coranalike the in 1 case. The HCMV positive rate was 63%, and total virus positive rate was 72.9%.It indicated HCMV was the main cause of infantal hepatitis syndrome.If after 4 weeks of systemic treatment the jaundice did not subside, we used SPECT to detect the causes. The results showed biliary tract obstruction in 11 cases and intrahepatic cholangiolitis in 2 cases. It indicated that hepatic and biliary tract obstruction of infantal hepatitis syndrome associated with HCMV infection.