Osmolality-induced tuning of action potentials in trigeminal ganglion neurons |
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| Authors: | Lei Chen Changjin Liu Lieju Liu |
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| Affiliation: | 1. Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China;2. Department of Neurobiology, Duke University, Durham, NC, USA;3. Department of Anesthesiology, Duke University, Durham, NC, USA;4. Department of Physiology, Nanjing Medical Univeristy, Nanjing, PR China |
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| Abstract: | The present study explored the effect of anisotonicity on action potential (AP) in cultured trigeminal ganglion (TG) neurons. We demonstrate that the number of evoked APs was increased by both hypo- and hypertonic treatment. Transient Receptor Potential Vanilloid 4 receptor (TRPV4) activator increased the number of APs, but only hypotonic-response was markedly blocked in TRPV4−/− mice. Additionally, inhibition of PKC attenuated hypotonicity-induced increase, whereas antagonism of PKA attenuated hypertonicity-response. We conclude that anisotonicity increases excitability of nociceptors, which might be involved in anisotonicity-induced nociception. The increase of APs by hypo- and hypertonicity is mediated through different receptor and intracellular signaling pathways. |
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| Keywords: | Osmolality Action potential TRPV4 Intracellular signaling pathway Nociception |
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