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An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis |
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| Authors: | Kazuhiko Nakamura Yoshimoto Sekine Noriyoshi Takei Yasuhide Iwata Katsuaki Suzuki Ayyappan Anitha Toshiya Inada Mutsuo Harano Tokutaro Komiyama Mitsuhiko Yamada Nakao Iwata Masaomi Iyo Ichiro Sora Norio Ozaki Hiroshi Ujike Norio Mori |
| Affiliation: | 1. Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan;2. Japanese Genetics Initiative for Drug Abuse (JGIDA), Japan;3. Institute of Neuropsychiatry, Seiwa Hospital, Tokyo, Japan;4. Department of Neuropsychiatry, Kurume University Graduate School of Medicine, Kurume, Japan;5. Department of Rehabilitation Medicine, Iida Hospital, Iida, Japan;6. National Institute of Mental Health, National Center of Neurology and Psychiatry, Ichikawa, Japan;g Department of Psychiatry, Fujita Health University School of Medicine, Houmei, Japan;h Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan;i Division of Psychobiology, Department of Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan;j Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan;k Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan |
| Abstract: | Methamphetamine continues to be the most widely abused drug in Japan. Chronic methamphetamine users show psychiatric signs, including methamphetamine psychosis. Monoamine oxidase A (MAOA) is one of the major enzymes responsible for the degradation of neurotransmitters. Abnormalities in MAO levels have been related to a wide range of psychiatric disorders. We examined whether or not the MAOA-u variable-number tandem repeat (VNTR) has a functional polymorphism in methamphetamine psychosis and whether or not such a polymorphism is related to the prolongation of psychosis. As expected, there was a significant difference in the MAOA-u VNTR between males with persistent versus transient methamphetamine psychosis (p = 0.018, odds ratio (OR) = 2.76, 95% CI: 1.18–6.46). Our results suggest that the high-activity allele class of MAOA-u VNTR in males may be involved in susceptibility to a persistent course of methamphetamine psychosis. We found no differences among females. The sample size of females with methamphetamine psychosis was too small to have significant analysis. |
| Keywords: | Methamphetamine psychosis Monoamine oxidase A Variable-number tandem repeat |
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