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索拉菲尼联合TACE治疗中晚期原发性肝癌的疗效观察及对患者血清AFP、VEGF水平的影响
引用本文:王健,李荣军,徐春霞,赵平,李炎,付丽,罗彦. 索拉菲尼联合TACE治疗中晚期原发性肝癌的疗效观察及对患者血清AFP、VEGF水平的影响[J]. 标记免疫分析与临床, 2019, 26(4): 641-644,670
作者姓名:王健  李荣军  徐春霞  赵平  李炎  付丽  罗彦
作者单位:泸州市中医院脾胃病科,四川泸州,646000;泸州市中医院重症医学科,四川泸州,646000
摘    要:目的探究索拉菲尼联合经导管动脉化疗栓塞(TACE)治疗中晚期原发性肝癌的疗效及对患者血清甲胎蛋白(AFP)、血管内皮生长因子(VEGF)水平的影响。方法回顾性分析我院2013年3月至2015年12月收治的中晚期原发性肝癌患者的临床资料,其中55例患者行索拉菲尼联合TACE治疗,纳入观察组,47例患者行单一TACE治疗,纳入对照组。于治疗12周后评价患者客观有效率(ORR)及疾病控制率(DCR),对患者进行随访评价远期疗效,测定治疗前后患者血清AFP、VEGF水平,记录并发症发生情况。结果对照组患者ORR及DCR分别为25.53%和63.82%,观察组患者为40.00%及78.18%,观察组DCR显著优于对照组(P <0.05);所有患者均获得随访,观察组患者2年累计生存率及中位PFS均显著高于对照组患者(P<0.05);两组患者治疗后血清AFP、VEGF水平显著下降(P<0.05),观察组患者下降幅度显著大于对照组患者(P<0.05);观察组皮疹、血压升高等不良反应发生率显著高于对照组患者(P<0.05)。结论索拉菲尼联合TACE治疗原发性肝癌可显著提高患者近期及远期疗效,降低血清AFP及VEGF水平,较单一TACE治疗效果更好。

关 键 词:索拉菲尼  经导管动脉化疗栓塞  原发性肝癌  血管内皮生长因子  疗效

The Curative Effect of Sorafenib Combined with TACE in the Treatment of Advanced Primary Liver Cancer and Its Influence on Serum AFP and VEGF Levels
WANG Jian,LI Rong-jun,XU Chun-xia,ZHAO Ping,LI Yan,FU Li,LUO Yan. The Curative Effect of Sorafenib Combined with TACE in the Treatment of Advanced Primary Liver Cancer and Its Influence on Serum AFP and VEGF Levels[J]. Labeled Immunoassays and Clinical Medicine, 2019, 26(4): 641-644,670
Authors:WANG Jian  LI Rong-jun  XU Chun-xia  ZHAO Ping  LI Yan  FU Li  LUO Yan
Affiliation:(Spleen and Stomach Disease,Luzhou Hospital of Traditional Chinese Medicine,Luzhou 646000,Chin;Department of Critical Care Medicine,Luzhou Hospital of Traditional Chinese Medicine,Luzhou 646000,China)
Abstract:WANG Jian;LI Rong-jun;XU Chun-xia;ZHAO Ping;LI Yan;FU Li;LUO Yan(Spleen and Stomach Disease,Luzhou Hospital of Traditional Chinese Medicine,Luzhou 646000,Chin;Department of Critical Care Medicine,Luzhou Hospital of Traditional Chinese Medicine,Luzhou 646000,China)
Keywords:Sorafenib  Transcatheter arterial chemoembolization  Primary liver cancer  Vascular endothelial growth factor  Curative effect
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