Refining memory assessment of elderly people with cognitive impairment: Insights from the short-term memory binding test |
| |
| Affiliation: | 1. School of Psychological Sciences and Health, Department of Psychology, University of Strathclyde, Glasgow, UK;2. Universidad Autónoma del Caribe, Barranquilla, Colombia;3. Alzheimer Scotland Dementia Research Centre and Neuroprogressive and Dementia Network, UK;4. Human Cognitive Neuroscience and Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, UK;5. School of Health in Social Science, University of Edinburgh, UK;6. Neurology Department, University Hospital la Paz, Madrid, Spain;7. Neurology Department, University Hospital Gregorio Marañón, Madrid, Spain;8. Magnetic Resonance Physics Group, Radiology and Nuclear Medicine Department, Erasmus MC, Rotterdam, The Netherlands;9. Neuroradiology Department, Hospital Ruber Internacional, Madrid, Spain;10. Department of Basic Psychology II (Cognitive Processes), Faculty of Psychology, Complutense University of Madrid, Spain;1. Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, Tübingen, Germany;2. Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, Heidelberg, Germany;3. Department of General, Visceral and Transplant Surgery, University Hospital Tübingen, Tübingen, Germany;1. State University Of Pará, Brazil;2. Hospital Cynthia Charone, Brazil;1. Department of Neuroscience, University of Sheffield, Sheffield, UK;2. IRCCS Istituto delle Scienze Neurologiche di Bologna, Diagnostica Funzionale Neuroradiologica, Bologna, Italy;3. School of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK;1. Cyclotron Research Center, University of Liège, Allée du 6 Août, B30, 4000 Liège, Belgium;2. Centre Hospitalier du Bois de l׳Abbaye et de Hesbaye, 4000 Liège, Belgium;3. Department of Psychology, Virginia Tech, Blacksburg, VA 24061, USA;4. Department of Psychology, University of California Davis, Davis, CA 95616, USA;5. Memory Clinic, CHU Liège, 4000 Liège, Belgium;1. Neuroscience Center, University of Helsinki, Helsinki, Finland;2. Laboratory of Clinical Psychophysiology, Department of Psychiatry, Hospital 12 de Octubre, Madrid, Spain;3. Department of Psychiatry, Hospital 12 de Octubre, Madrid, Spain;4. Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain;5. Department of Psychiatry, Complutense University of Madrid, Madrid, Spain;6. Department of Basic Psychology II (Cognitive Processes), Complutense University of Madrid, Madrid, Spain |
| |
| Abstract: | Alzheimer's disease (AD) affects temporary memory for bound features more remarkably than for individual features. Such selective impairments manifest from presymptomatic through dementia stages via titration procedures. A recent study suggested that without titration and with high memory load the binding selectivity may disappear in people at risk of AD such as those with Mild Cognitive Impairment (MCI). We compared data from two studies on temporary binding which assessed people with MCI and controls using different memory loads (2 or 3 items). Selective binding impairments were found in MCI, but relative to controls, such selectivity was contingent upon memory load (i.e., present with 2 items). Further analysis with MCI people who tested positive to neuroimaging biomarkers (i.e., hippocampal atrophy) confirmed that this specific binding impairments are a feature of prodromal AD. The temporary binding task has been recently suggested by consensus papers as a potential screening tool for AD. The results presented here inform on task properties that can maximize the reliability of this new assessment tool for the detection of memory impairments in prodromal cases of AD. |
| |
| Keywords: | Short-term memory binding Mild cognitive impairment Prodromal Alzheimer's disease Neuropsychological assessment Early detection |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
