Association between serum 25-hydroxyvitamin D concentration and severity of first-diagnosed bullous pemphigoid in older adults |
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| Institution: | 1. Department of Dermatology, Angers University Hospital, Angers, France;2. School of Medicine, Angers, France;3. INSERM U1066, Micro et Nanomédecines Biomimétiques, IBS-CHU, 4 rue Larrey, F-49933 Angers, France;4. Department of Geriatric Medicine, Angers University Hospital, University Memory Clinic of Angers, Research Center on Autonomy and Longevity, UPRES EA 4638, University of Angers, UNAM, Angers, France;5. Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada;1. Verde Valley Medical Center, Cottonwood, Arizona;2. Conjoint Allergy/Immunology Fellowship, University Hospitals Regional Medical Centers, Cleveland, Ohio;3. Allergy/Immunology Associates Inc, Mayfield Heights, Ohio;1. Unidad de Gestión Clínica de Dermatología Médico Quirúrgica y Venereología, Hospital Universitario Virgen de las Nieves, Granada, España;2. Unidad de Gestión Clínica de Anatomía Patológica, Hospital Universitario Virgen de las Nieves, Granada, España;1. Department of Urology, Hallym University Kangnam Sacred Heart Hospital, Seoul, Republic of Korea;2. Department of Urology, Kwangju Christian Hospital, Gwangju, Republic of Korea;3. Department of Urology, Hanyang University Guri Hospital, Guri, Republic of Korea;4. Department of Urology, National Police Hospital, Seoul, Republic of Korea;5. Department of Urology, Uijeongbu St. Mary''s Hospital, The Catholic University of Korea, Seoul, Republic of Korea;6. Department of Urology, Korea University Ansan Hospital, Ansan, Republic of Korea;7. Department of Urology, Dongguk University Gyeongju Hospital, Gyeongju, Republic of Korea;8. Department of Urology, Konyang University Hospital, Daejeon, Republic of Korea;9. Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea;10. Department of Urology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea;11. Department of Urology, DanKook University Hospital, Cheonan, Republic of Korea;1. LTCI, Télécom ParisTech, Université Paris-Saclay, Paris, France;2. Université Alioune Diop de Bambey, Bambey, Senegal;3. Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel;4. DI ENS, ENS, CNRS, PSL University, Paris, France;5. Inria, Paris, France;1. Latvian Biomedical Research and Study Centre, Ratsupites iela 1, Riga LV-1067, Latvia;2. Faculty of Biology, University of Latvia, Jelgavas Street 1, Riga LV-1004, Latvia;3. Riga Stradins University, Dzirciema iela 16, Riga LV-1007, Latvia;1. Evidence-Based Medicine Center, Xuanwu Hospital, Capital Medical University, Beijing, China;2. Key Laboratory for Neurodegenerative Disease of Ministry of Education, China;3. Medical Affairs Department, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China;4. Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China;5. Geriatric Department, Capital Medical University, Beijing, China |
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| Abstract: | BackgroundHigher vitamin D status has been associated with symptom improvement and decreased risk of various autoimmune disorders. Our objective was to determine whether higher serum 25-hydroxyvitamin D (25OHD) concentration correlated with less severe first-diagnosed bullous pemphigoid (BP) in older inpatients.MethodsThis cross-sectional study was performed from November 2012 to February 2014 among 30 consecutive older inpatients (21 women; mean ± SD, 83 ± 7 years; all Caucasian) with a de novo diagnosis of active BP recruited in the Department of Dermatology of Angers University Hospital, France. The severity of BP was graded clinically on the basis of i) the number of bullae during the first three days of hospitalization (grade 0–4, worse), and ii) the extent of the lesions (grade 0–5, worse).ResultsSixteen participants had ≤ 5 bullae at the time of diagnosis, 8 had 6–20 bullae, 3 had 20–50 bullae, and 3 had >50 bullae. The lesions were spread over 5 cutaneous areas in 5 participants (17%). The median 25OHD concentration was 23 IQR, 16–42] nmol/L. Serum 25OHD concentration was inversely correlated with the bullae grade (ρ = ? 0.38, p = 0.04) and the lesion extension grade (ρ = ? 0.50, p = 0.005).ConclusionsHigher serum 25OHD concentration correlated with less severe BP prior to initiation of treatment among our sample of older inpatients. This result suggests that vitamin D may be involved in the pathophysiology of BP and could serve as prognostic biomarker of BP. |
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| Keywords: | Vitamin D Bullous pemphigoid Severity Older adults |
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