| 卵巢癌患者外周血Treg细胞与机体免疫抑制及肿瘤标志物的关系分析 |
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| 引用本文： | 崔彭华,李志艳,张玉娟,刘莉.卵巢癌患者外周血Treg细胞与机体免疫抑制及肿瘤标志物的关系分析[J].标记免疫分析与临床,2019,26(6):1016-1019. |
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| 作者姓名： | 崔彭华 李志艳 张玉娟 刘莉 |
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| 作者单位： | 承德医学院附属医院妇科,河北承德,067000;承德医学院附属医院检验科,河北承德,067000 |
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| 摘 要： | 目的探究卵巢癌患者外周血Treg细胞与机体免疫抑制及肿瘤标志物的关系。方法选择2016年10月至2017年10月卵巢癌患者共58例作为研究组,同期卵巢良性肿瘤患者50例作为对照组,健康者50例作为健康对照组(简称健康组)。比较三组受试者Treg、Th1、Th2、血清CA19-9、CA125、IL-6、IL-10、TNF-α、IL-12,并分析Treg与卵巢癌患者Th1、Th2、血清CA19-9、CA125、IL-6、IL-10、TNF-α、IL-12的相关性。结果研究组的Treg、Th2细胞水平显著高于对照组和健康组(P<0.05),Th1显著低于对照组和健康组(P<0.05)。研究组的CA19-9和CA125水平显著高于对照组和健康组(P<0.05)。研究组血清TNF-α、IL-2显著低于对照组和健康组(P<0.05),IL-6和IL-10显著高于对照组和健康组(P<0.05)。卵巢癌患者Treg与CA125、IL-6、IL-10呈现显著正相关关系(P<0.05),卵巢癌患者Treg与TNF-α、IL-12呈现显著负相关关系(P<0.05)。结论卵巢癌Treg与CA125、IL-6、IL-10呈现显著正相关关系,与TNF-α、IL-12呈现显著负相关关系,卵巢癌患者体内存在Th1/Th2平衡向Th2漂移,可能与Treg上调有关。
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| 关 键 词： | 卵巢癌 调节性T细胞 肿瘤标志物 Th1 Th2 |
The Relationship Between Peripheral Blood Treg Cells and Immune Suppression and Tumor Markers in Patients with Ovarian Cancer |
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| CUI Peng-hua,LI Zhi-yan,ZHANG Yu-juan,LIU Li.The Relationship Between Peripheral Blood Treg Cells and Immune Suppression and Tumor Markers in Patients with Ovarian Cancer[J].Labeled Immunoassays and Clinical Medicine,2019,26(6):1016-1019. |
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| Authors: | CUI Peng-hua LI Zhi-yan ZHANG Yu-juan LIU Li |
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| Institution: | (Department of Gynaecology,Affiliated Hospital of Chengde Medical College,Chengde 067000,China;Clinical Laboratory,Affiliated Hospital of Chengde Medical College,Chengde 067000,China) |
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| Abstract: | CUI Peng-hua;LI Zhi-yan;ZHANG Yu-juan;LIU Li(Department of Gynaecology,Affiliated Hospital of Chengde Medical College,Chengde 067000,China;Clinical Laboratory,Affiliated Hospital of Chengde Medical College,Chengde 067000,China) |
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| Keywords: | Ovarian cancer Regulatory T cells Tumor marker Th1 Th2 |
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