| 短暂性脑缺血发作患者血小板活化因子与血栓烷B2检测及临床意义 |
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| 引用本文： | 曹红翠,杨云梅,陈晓明,许文荣,朱伟. 短暂性脑缺血发作患者血小板活化因子与血栓烷B2检测及临床意义[J]. 中华急诊医学杂志, 2004, 13(1): 39-40,i003 |
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| 作者姓名： | 曹红翠 杨云梅 陈晓明 许文荣 朱伟 |
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| 作者单位： | 310003,杭州,浙江大学医学院附属第一医院传染内科;310003,杭州,浙江大学医学院附属第一医院干部病房;江苏大学医学技术学院检验系 |
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| 基金项目： | 浙江省教育厅科研资金项目资助 ( 2 0 0 2 2 0 798) |
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| 摘 要： | 目的 通过测定短暂性脑缺血发作 (transientischemicattack ,TIA)患者血浆血小板活化因子(plateletactivatingfactor,PAF)、血栓烷B2 (thromboxaneB2 ,TXB2 )水平 ,研究其含量变化在TIA发生发展中的作用。方法 分别采用反相高效液相色谱法 (rHPLC)、放射免疫法 (RIA)测定 5 0例TIA和 6 0例健康对照组的血浆PAF、TXB2 值。结果 TIA患者血浆PAF、TXB2 均明显高于对照组 ,并呈显著性差异 (P <0 0 1,P <0 0 1)。结论 PAF和TXB2 在TIA的发生、发展中发挥了重要作用。血浆PAF、TXB2 水平的检测 ,对TIA疗效和预后判断具有指导意义。
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| 关 键 词： | 短暂性脑缺血发作 血小板活化因子 血栓烷B2 |
| 修稿时间： | 2003-08-09 |
The changes and clinical significance of plasma PAF and TXB2 in patients with TIA |
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| CAO Hongcui,YANG Yunmei,CHEN Xiaoming,et al.. The changes and clinical significance of plasma PAF and TXB2 in patients with TIA[J]. Chinese Journal of Emergency Medicine, 2004, 13(1): 39-40,i003 |
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| Authors: | CAO Hongcui YANG Yunmei CHEN Xiaoming et al. |
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| Affiliation: | CAO Hongcui,YANG Yunmei,CHEN Xiaoming,et al.The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou310003,China |
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| Abstract: | Objective To explore the roles and clinical significance of plasma PAF and TXB 2 by measuring the changes of their levels in patients with TIA.Methods 50 patients mean age of 68.6.with TIA were included Control group consisted of 60 persons,including blood donors and healthy persons.Plasma PAF and TXB 2 levels in 50 patients and 60 controls were measured separately by reversed phase high-performance liquid chromatographic technique(rHPLC) established by our lab and radioimmunoassay(RIA).Results The levels of plasma PAF and TXB 2 in patients with TIA were higher than those in the controls'(P<0.01).Conclusion PAF and TXB 2 play important roles in occurrence and development of TIA.PAF and TXB 2 levels are important in evaluating TIA treatment and prognosis. |
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| Keywords: | Transient ischemic attack Platelet activating factor Thromboxane B 2 |
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