人参皂甙脂质体（GSL）的研制

 为增强人参皂甙在体内的靶向性以提高其抗癌疗效，同时提高其生物利用度，对人参皂甙脂质体（ＧＳＬ）的制备进行了初步研究。采用薄膜分散法制备了６８Ｌ并对其理化性质进行了考察。显微及电镜鉴别结果显示，所制得的ＧＳＬ以复层脂质体为主，单层脂质体少数，碎片很少；采用标准品对照法测得其包封率为５１．４％；用热差分析法测相变温度为７０Ｃ；使用多功能图象仪测得粒径大多在０．７～１．２μｍ之间。研究结果表明，用所报道的薄膜分散法制备的ＧＳＬ有较理想的包装率和较适宜的粒径范围，人参皂甙完全可能做成载药脂质体。这一结论对人参皂甙的进一步开发和利用，尤其是在人参皂甙对肿瘤的治疗方面将有十分重要的作用。

Ginseng saponin liposome(GSL)

There have been a number reports on Ginseng saponin and liposome but on Gisengsoponin liposome, Reports showed that entrapped drug increases thepasssge to ce11s and maydecrease the dosage of drug and metamorphosis reaction;Ginseng saponin can directly kill orreverse cancer cells,it acts on liver principally after entrapped drug is absorbed by reticuloendothelium and orgns such as liver and spleen。Prepared liposome , Ginseng saponin will improvethe thereapeutic effects。The GSL was prepared by film dispersion method and its physical andchemicaI nature was studied.The GSL prepared contained muItilamellar vesicles,The phase inversion temperature was 70C , the percentage of particle size 0.7～1.2 μm,and the entrapmentrate 51.4%。