Initial experience with Tc-99m-HM-PAO in the study of brain tumors |
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| Authors: | John W. Babich Frank Keeling Margaret A. Flower Lazzaro Repetto Anthony Whitton Sue Fielding Ann Fullbrook Robert J. Ott V. Ralph McCready |
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| Affiliation: | (1) Department of Medical Physics, The Royal Marsden Hospital, SM2 5PT Sutton, Surrey, UK;(2) Department of Nuclear Medicine, The Royal Marsden Hospital, SM2 5PT Sutton, Surrey, UK;(3) Department of Medicine, The Royal Marsden Hospital, SM2 5PT Sutton, Surrey, UK;(4) Department of Radiotherapy, The Royal Marsden Hospital, SM2 5PT Sutton, Surrey, UK;(5) Institute of Cancer Research, SM2 5PT Sutton, Surrey, UK |
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| Abstract: | ![]()
A preliminary study of the distribution of the 99mTc complex of hexamethylpropylene amine oxime (HM-PAO) in 12 patients with brain neoplasms before, during, and after radiotherapy has been performed. Untreated brain tumors were found to exhibit a range of 99mTc-HM-PAO uptake, varying from areas of markedly increased isotope activity to photopenic areas, when compared to normal brain tissue. A ratio of 99mTc-HM-PAO tumor uptake to contralateral normal tissue uptake was calculated prior to and during radiotherapy. This ratio tended to return towards unity in lesions responding to therapy. A predictable alteration in whole brain 99mTc-HM-PAO uptake during radiotherapy was not demonstrated. Unlike the radiolabeled amines, 99mTc-HM-PAO localizes in primary tumors, probably indicating that its uptake mechanism is independent of non specific amine receptors. 99mTc-HM-PAO may be useful in the study of brain tumor physiology and response to therapy. |
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| Keywords: | 99mTc-HM-PAO Brain tumors Radiotherapy Brain tumor perfusion |
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