| 法莫替丁片的溶出度与生物利用度 |
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| 引用本文： | 陆彬,贺英菊,郭平,叶利民. 法莫替丁片的溶出度与生物利用度[J]. 药学学报, 1992, 27(4): 303-307 |
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| 作者姓名： | 陆彬 贺英菊 郭平 叶利民 |
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| 作者单位： | 华西医科大学药学院，华西医科大学药学院，华西医科大学药学院，华西医科大学药学院 成都 610041，成都 610041，成都 610041，成都 610041 |
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| 基金项目： | 重庆西南制药一厂资助项目 |
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| 摘 要： | 采用溶出度自动测试系统测定了法莫替丁片的溶出度,15min平均累积溶出97.40±0.31%。6名志愿健康受试者口服法莫替丁片40mg后,用HPLC柱切换技术测定其血药浓度,将不同血药浓度对时间的数据进行曲线拟合,计算值与实测值比较,可用一室模型描述。以统计矩计算得T1/2=2.92h,与口服溶液相比,Frel=118.8%。
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| 关 键 词： | 法莫替丁 溶出度 高效液相色谱 生物利用度 |
| 收稿时间： | 1990-11-19 |
DISSOLUTION RATE AND BIOAVAILABILITY OF FAMOTIDINE TABLETS |
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| B Lu,YJ He,P Guo,LM Ye. DISSOLUTION RATE AND BIOAVAILABILITY OF FAMOTIDINE TABLETS[J]. Acta pharmaceutica Sinica, 1992, 27(4): 303-307 |
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| Authors: | B Lu YJ He P Guo LM Ye |
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| Affiliation: | School of Pharmacy, West China University of Medical Sciences, Chengdu. |
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| Abstract: | An automated dissolution test system was used for the determination of the dissolution rate of famotidine tablets, and a mean cumulative dissolution rate of 97.40 +/- 0.31% in 15 min was obtained. To each of six healthy volunteers, 40 mg of famotidine tablets were administered orally, then an automated HPLC with switching column system was used to analyze famotidine in plasma. Variation of drug concentration vs time were fitted to curves. By comparison of calculated values with observed ones, the results could be described as one-compartment model in human. According to a statistic moment algorithm, the results of calculation showed that T1/2 = 2.92 h and Frel = 118.8%. |
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| Keywords: | Famotidine Dissolution rate High performance liquid chromatography Bioavailability |
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