局部注射复方倍他米松和醋酸曲安奈德治疗斑秃的疗效观察

目的比较局部注射复方倍他米松注射液和醋酸曲安奈德注射液治疗斑秃的临床疗效及不良反应。方法182例斑秃患者随机分为治疗组和对照组各91例,治疗组采用复方倍他米松注射液1ml加2%利多卡因2ml,0.2ml/cm2局部注射,每4周1次,连续3次,对照组采用醋酸曲安奈德注射液1ml加2%利多卡因2ml,0.2ml/cm2局部注射,每周1次,连续3周,治疗组和对照组均同时口服维生素B6片(20mg,3次/d),谷维素片(20mg,3次/d),分别观察治疗后第4、8、12周的临床疗效及不良反应。结果治疗第4周时治疗组和对照组有效率分别为17.58%和30.77%,P<0.05;第8周时治疗组和对照组有效率分别为46.15%和53.85%,P>0.05;第12周时治疗组和对照组有效率分别为83.52%和70.33%,P<0.05。结论局部注射糖皮质激素治疗斑秃疗效确切,早期醋酸曲安奈德组疗效高于复方倍他米松组,但后期复方倍他米松组疗效高于醋酸曲安奈德组。

Clinical effect of Compound Betamethasone and Triamcinolone Acetonide Acetate in treating alopecia areata by local injection

Objective To compare the clinical potency and untoward reactions of compound betamethasone and triamcinolone acetonide acetate in treating alopecia areata by local injection.Methods Totally 182 patients with alopecia areata were randomly divided into treatment group(n=91) and control group(n=91),using compound betamethasone(1ml and 2ml of 2%lidocaine,0.2ml/cm2)for treatment group by local injection,once per 4 weeks for 3 times directly.The control group were locally injected with triamcinolone acetonide acetate(1ml and 2ml of 2%lidocaine,0.2ml/cm2),once a week for 3 times directly,then observed the clinical potency and untoward reactions at 4th、8th、12th weeks respectively.All the patients were received VitaminB6 20 mg and oryzanol 20 mg,po,tid.Results At the 4th week,the effective power of treatment group and control group was 17.58% and 30.77%(P>0.05),significant differences were found among the tow groups.At the 8th week,the effective power of the two groups was 46.15% and 53.85% respectively(P>0.05).The treatment group’s effective power(83.52%) was higher than that of control group(70.33%) at the 12th week(P<0.05),remarkable differences were found.Conclusions The curative effect of local injecting glucocorticoid in treating alopecia areata was precisely.In early treatment triamcinolone acetonide acetate’s effective power was better.But the effective power of compound betamethasone was exceed in long term observation.