国产盐酸氯普鲁卡因用于神经刺激仪引导下的闭孔神经阻滞的临床研究

目的：探讨国产盐酸氯普鲁卡因用于神经刺激仪引导下的闭孔神经阻滞用于经尿道膀胱肿瘤电切术（Transurethralresection of bladder tumor,TURBT）的可行性。方法：膀胱侧壁肿瘤择期行TURBT的男性患者60例,ASAI～Ⅱ级,采用蛛网膜下腔麻醉,辅以神经刺激仪引导闭孔神经阻滞。随机分为实验组和对照组,每组30例。闭孔神经阻滞局麻药10 ml;实验组采用2%氯普鲁卡因（含1∶20万U肾上腺素）,对照组采用1%利多卡因。观察并记录闭孔神经阻滞的麻醉效果及并发症。结果：两组闭孔神经阻滞的麻醉效果和安全性没有显著差异（P〉0.05）。结论：2%氯普鲁卡因用于神经刺激仪引导下的闭孔神经阻滞安全、有效。

Domestic chlorprocaine hydrochloride for nerve stimulator-guided obturator nerve block

Objective:To explore the feasibility of domestic chlorprocaine hydrochloride in nerve stimulator guided obturator nerve block(ONB) in patients undergoing transurethral resection of bladder tumor(TURBT).Methods: Sixty male patients with the lateral bladder wall tumor,ASA I to Ⅱ,were randomly divided into two groups: experimental group(n= 30) and control group(n=30).Spinal anesthesia plus nerve stimulator guided ONB were used in the operations.2% chloroprocaine(contain 1:200 000 U adrenaline) was given to the experimental group and 1% lidocaine(10 ml) to the control group.The anesthesia effects and side effects of ONB were recorded.Results:There was no significant difference between the two groups in anesthesia effect and safety(P >0.05).Conclusion:The trial showed that 2% chloroprocaine in nerve stimulator guided ONB can exert a satisfactory anesthesia effect.