| 尖锐湿疣患者中趋化因子受体CXCR1、CXCR4及其配体的水平 |
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| 引用本文： | 杨桂兰,杨永茂,杨金升,杜华,张燕玲,哈小琴.尖锐湿疣患者中趋化因子受体CXCR1、CXCR4及其配体的水平[J].西北国防医学杂志,2011,32(2):90-91. |
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| 作者姓名： | 杨桂兰 杨永茂 杨金升 杜华 张燕玲 哈小琴 |
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| 作者单位： | 兰州军区兰州总医院皮肤科,甘肃,兰州,730050 |
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| 摘 要： | 目的：测定趋化因子受体CXCR1与CXCR4及其配体在尖锐湿疣（CA）患者中的水平。方法：病程大于3个月的CA患者30例,实时定量PCR法检测外周血单个核细胞（PBMC）及皮损中CXCR1与CXCR4mRNA表达水平,流式细胞仪分析外周血白细胞CXCR1与CXCR4的表达情况,ELISA检测血清IL-8与SDF-1α的水平;设30例健康人为正常对照。结果：CX-CR4 mRNA与SDF-1α在CA患者中的水平显著高于对照组（均P〈0.01）。结论：CXCR4与SDF-1α可能参与了CA的发病机制。
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| 关 键 词： | 尖锐湿疣 受体 趋化因子 CXCR1 CXCR4 |
Chemokine receptors CXCR1,CXCR4 and ligands levels in patients with condyloma acuminatum |
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| Institution: | YANG Gui-lan,YANG Yong-mao,YANG Jin-sheng,et al.(Department of Dermatology,Lanzhou General Hospital,Lanzhou Command,Lanzhou730050,China) |
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| Abstract: | Objective:To determine the levels of chemokine receptors CXCR1,CXCR4 and IL-8,SDF-1α in codyloma acuminatum(CA) patients.Methods: Real-time quantitative PCR technique was applied to quantitatively analyze CXCR1 and CXCR4 mRNA expression levels in peripheral blood mononuclear cells(PBMC) and lesions,two-colour flow cytometry was used to detect CXCR1 expression cells in blood leucocytes,serum levels of IL-8 and SDF-1α were measured by double antibody sandwich enzyme-linked immunosorbent assay(ELISA) in 30 cases of diagnosed CA patients(> 3 months of the course of disease) and 30 healthy controls.Results:The CXCR4 and SDF-1α levels in CA patients were significantly higher than that of the normal controls(P<0.01).Conclusion:The increased CXCR4 and SDF-1α may be involved in the pathogenesis of CA. |
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| Keywords: | CXCR1 CXCR4 |
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