妊娠期肝内胆汁淤积症产妇外周血调节性T细胞和辅助性T细胞表达分析

目的：分析妊娠期肝内胆汁淤积症（ICP）产妇外周血调节性T细胞和辅助性T细胞表达水平。方法：连续选择近期入院分娩的23例ICP产妇,入选对象均接受了外周血调节性T细胞（CD4＋CD25＋Treg和CD4＋CD25＋Foxp3＋Treg）和辅助性T细胞（CD＋3、CD＋4、CD＋8、CD＋4/CD＋8）检测,并与同期住院正常怀孕产妇（对照组,20例）相同测试结果比较。结果：调节性T细胞检测数据比较中,ICP组血清CD4＋CD25＋Treg和CD4＋CD25＋Foxp3＋Treg水平明显低于对照组（P均〈0.05～0.01）。辅助性T细胞检测数据比较中,ICP组血清CD＋4/CD＋8表达水平明显高于对照组,而CD＋8表达水平则显著低于后者（P均〈0.05～0.01）。结论：ICP产妇存在着外周血调节性T细胞和辅助性T细胞异常表达。

Expression analysis of peripheral blood regulatory T cell and helper T cell in pregnant women with intrahepatic cholestasis of pregnancy

Objective:To analyse the expression level of peripheral blood regulatory T cell and helper T cell in pregnant women with intrahepatic cholestasis of pregnancy(ICP).Methods: A total of 23 ICP puerperas who had delivery in the hopsital recently were continuously selected,peripheral blood regulatory T cell(CD4+ CD25+ Treg and CD4+ CD25+ Foxp3+Treg) and helper T cell(CD+3,CD+4,CD+8,CD+4/ CD+8) were detected in all selected objects and compared with those of the normal pregnant women(control group,20 women).Results:For the regulatory T cell data,serum CD4+ CD25+ Treg and CD4+ CD25+ Foxp3+Treg level in ICP group were obviously lower than those of the control group(P<0.05 to 0.01).For the helper T cell data,serum CD+4/ CD+8 expression level in ICP group was significantly higher than that of the control group,however,the expression level of CD+8 was obviously lower(P<0.05 to 0.01).Conclusion:ICP puerperas have abnormal expression in both peripheral blood regulatory T cell and helper T cell.