| R-huEPO对颅脑创伤患者血清S-100β和IL-10影响的临床研究 |
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| 引用本文： | 刘宗宝,雷鹏,杨钟灵.R-huEPO对颅脑创伤患者血清S-100β和IL-10影响的临床研究[J].西北国防医学杂志,2011,32(2):84-86. |
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| 作者姓名： | 刘宗宝 雷鹏 杨钟灵 |
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| 作者单位： | 兰州军区兰州总医院神经外科,甘肃,兰州,730050 |
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| 基金项目： | 全军"十一五"医学基金资助项目 |
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| 摘 要： | 目的：研究重组人促红细胞生成素（recombinant human erythropoietin,r-huEPO）对颅脑创伤患者血清S-100β蛋白和IL-10的影响,评价其临床保护作用。方法：31例患者随机分为对照组与治疗组,其中治疗组于规定时间皮下注射r-huEPO,对照组不予r-huEPO处理,其他治疗两组相同。两组均在伤后第1、4、7、10、14天静脉采血,利用ELISA法测定S-100β蛋白和IL-10含量,并与患者临床征象作比较。结果：治疗组患者颅内压及脑水肿较对照组减轻,且GCS评分升高;血清S-100β蛋白含量低于对照组,IL-10含量高于对照组,差异均有统计学意义（P〈0.05）。结论：利用r-huEPO进行红细胞动员,可通过各种机制抑制颅脑创伤后继发的病理损害及其过度炎症反应,对颅脑创伤具有神经保护作用。
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| 关 键 词： | 颅脑创伤 促红细胞生成素 S-100β蛋白 IL-10 |
Effect of r-huEPO on S-100 β protein and IL-10 in the patients with traumatic brain injury |
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| LIU Zong-bao,LEI Peng,YANG Zhong-ling.Effect of r-huEPO on S-100 β protein and IL-10 in the patients with traumatic brain injury[J].Medical Journal of National Defending Forces in Northwest China,2011,32(2):84-86. |
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| Authors: | LIU Zong-bao LEI Peng YANG Zhong-ling |
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| Institution: | .(Department of Neurosurgery,Lanzhou General Hospital,Lanzhou Command,PLA,Lanzhou 730050,China) |
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| Abstract: | Objective:To study the protective effect of r-huEPO on S-100 β protein and IL-10 in the patients with traumatic brain injury.Methods: Thirty-one cases were randomly divided into treatment group and control group.R-huEPO was injected to the treatment group but not to the control group,and other treatments were the same.S-100β protein and IL-10 were measured using ELISA analysis at d1,d4,d7,d10 and d14 after injury.Results:In treatment group,intracranial pressure and cerebral edema were reduced,with higher GCS score(P<0.05).The expression of S-100β protein was lower and IL-10 was higher in the treatment group compared with the control group and the difference was statistically significant(P<0.05).Conclusion: R-huEPO has a protective effect to the nervous system. |
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| Keywords: | IL-10 |
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