Histopathological Changes of Inner Retina,Optic Disc,and Optic Nerve in Rabbit with Advanced Retinitis Pigmentosa |
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| Authors: | Ken Asakawa Hitoshi Ishikawa Shigekazu Uga Kimiyo Mashimo Mineo Kondo Hiroko Terasaki |
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| Affiliation: | 1. Department of Orthoptics and Visual Science, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan;2. Department of Ophthalmology, School of Medicine, Kitasato University, Kanagawa, Japan;3. Department of Ophthalmology, School of Medicine, Kitasato University, Kanagawa, Japan;4. Department of Ophthalmology, School of Medicine, Mie University Graduate School, Mie, Japan;5. Department of Ophthalmology, School of Medicine, Nagoya University Graduate School, Nagoya, Japan |
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| Abstract: | ![]()
We observed the histopathological changes of retinal ganglion cells (RGCs), optic disc, and optic nerve in rabbit with advanced retinitis pigmentosa (RP). Wild-type (WT) and rhodopsin transgenic (Tg) of RP rabbits were used at age 24 months. Light and electron microscopy were used to observe the retina, optic disc, and optic nerve. RGCs were also confirmed by immunofluorescent staining with a TUJ-1 monoclonal antibody. In addition to the rod and cone degeneration, we observed the astrocyte infiltration of the optic disc due to the damage of small RGCs and nerve fibres and atrophy of small optic nerve fibres. They subsequently lead to the optic disc excavation and atrophy of the optic nerve. Consequently, our histopathological study clarified that not only the outer retina but also the inner retina, the optic disc, and the optic nerve were also affected in the late stages of RP rabbit. |
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| Keywords: | Optic disc optic nerve rabbit retinal ganglion cell retinitis pigmentosa |
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