A homogenous nanoporous pulmonary drug delivery system based on metal-organic frameworks with fine aerosolization performance and good compatibility |
| |
| Authors: | Yixian Zhou Boyi Niu Biyuan Wu Sulan Luo Jintao Fu Yiting Zhao Guilan Quan Xin Pan Chuanbin Wu |
| |
| Affiliation: | 1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;2. College of Pharmacy, Jinan University, Guangzhou 510632, China |
| |
| Abstract: | ![]()
Pulmonary drug delivery has attracted increasing attention in biomedicine, and porous particles can effectively enhance the aerosolization performance and bioavailability of drugs. However, the existing methods for preparing porous particles using porogens have several drawbacks, such as the inhomogeneous and uncontrollable pores, drug leakage, and high risk of fragmentation. In this study, a series of cyclodextrin-based metal-organic framework (CD-MOF) particles containing homogenous nanopores were delicately engineered without porogens. Compared with commercial inhalation carrier, CD-MOF showed excellent aerosolization performance because of the homogenous nanoporous structure. The great biocompatibility of CD-MOF in pulmonary delivery was also confirmed by a series of experiments, including cytotoxicity assay, hemolysis ratio test, lung function evaluation, in vivo lung injury markers measurement, and histological analysis. The results of ex vivo fluorescence imaging showed the high deposition rate of CD-MOF in lungs. Therefore, all results demonstrated that CD-MOF was a promising carrier for pulmonary drug delivery. This study may throw light on the nanoporous particles for effective pulmonary administration. |
| |
| Keywords: | Pulmonary drug delivery Metal-organic framework Inhalable dry powder Nanoporous particle ANOVA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" analysis of variance BALF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" bronchoalveolar lavage fluid BET" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" Brunauer–Emmett–Teller CCK-8" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" cell counting kit-8 CD-MOF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" cyclodextrin-based metal-organic framework CD-MOF-K" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" ketoprofen-loaded cyclodextrin-based metal-organic framework CD-MOF-R" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" rhodamine B-loaded cyclodextrin-based metal-organic framework dynamic lung compliance CF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0125" }," $$" :[{" #name" :" text" ," _" :" commercial formulation CTAB" },{" #name" :" keyword" ," $" :{" id" :" kwrd0135" }," $$" :[{" #name" :" text" ," _" :" cetyl trimethyl ammonium bromide DPPC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0145" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" __text__" ," _" :" 1,2-dipalmitoyl-" },{" #name" :" italic" ," _" :" sn" },{" #name" :" __text__" ," _" :" -glycero-3-phosphocholine FBS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0155" }," $$" :[{" #name" :" text" ," _" :" fetal bovine serum FDA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0165" }," $$" :[{" #name" :" text" ," _" :" U.S. Food and Drug Administration FPF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0175" }," $$" :[{" #name" :" text" ," _" :" fine particle fraction GSD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0185" }," $$" :[{" #name" :" text" ," _" :" geometric standard deviation HE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0195" }," $$" :[{" #name" :" text" ," _" :" Hematoxylin-Eosin HPLC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0205" }," $$" :[{" #name" :" text" ," _" :" high performance liquid chromatography LDH" },{" #name" :" keyword" ," $" :{" id" :" kwrd0215" }," $$" :[{" #name" :" text" ," _" :" lactate dehydrogenase LPS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0225" }," $$" :[{" #name" :" text" ," _" :" lipopolysaccharide MFI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0235" }," $$" :[{" #name" :" text" ," _" :" mean fluorescence intensity MMAD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0245" }," $$" :[{" #name" :" text" ," _" :" mean mass aerodynamic diameter MOF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0255" }," $$" :[{" #name" :" text" ," _" :" metal-organic framework NGI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0265" }," $$" :[{" #name" :" text" ," _" :" next generation pharmaceutical impactor PBS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0275" }," $$" :[{" #name" :" text" ," _" :" phosphate buffered solution PVP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0285" }," $$" :[{" #name" :" text" ," _" :" poly(vinyl pyrrolidone) PXRD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0295" }," $$" :[{" #name" :" text" ," _" :" powder X-ray diffraction lung resistance SD rat" },{" #name" :" keyword" ," $" :{" id" :" kwrd0315" }," $$" :[{" #name" :" text" ," _" :" Sprague–Dawley rat SEM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0325" }," $$" :[{" #name" :" text" ," _" :" scanning electron microscopy SLF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0335" }," $$" :[{" #name" :" text" ," _" :" simulated lung fluid |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
