Biomimetic carbon nanotubes for neurological disease therapeutics as inherent medication |
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| Affiliation: | 1. Translational Medicine Center, Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China;2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China |
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| Abstract: | Nowadays, nanotechnology is revolutionizing the approaches to different fields from manufacture to health. Carbon nanotubes (CNTs) as promising candidates in nanomedicine have great potentials in developing novel entities for central nervous system pathologies, due to their excellent physicochemical properties and ability to interface with neurons and neuronal circuits. However, most of the studies mainly focused on the drug delivery and bioimaging applications of CNTs, while neglect their application prospects as therapeutic drugs themselves. At present, the relevant reviews are not available yet. Herein we summarized the latest advances on the biomedical and therapeutic applications of CNTs in vitro and in vivo for neurological diseases treatments as inherent therapeutic drugs. The biological mechanisms of CNTs-mediated bio-medical effects and potential toxicity of CNTs were also intensely discussed. It is expected that CNTs will exploit further neurological applications on disease therapy in the near future. |
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| Keywords: | Carbon nanotubes Nervous system diseases Drug delivery Therapeutic drug Inherent medication Toxicity AD},{#name:keyword,$:{id:kwrd0045},$$:[{#name:text,_:Alzheimer's disease ALS},{#name:keyword,$:{id:kwrd0055},$$:[{#name:text,_:amyotrophic lateral sclerosis aSWCNTs},{#name:keyword,$:{id:kwrd0065},$$:[{#name:text,_:aggregated SWCNTs BBB},{#name:keyword,$:{id:kwrd0075},$$:[{#name:text,_:blood–brain barrier CNS},{#name:keyword,$:{id:kwrd0085},$$:[{#name:text,_:central nervous system CNT-N},{#name:keyword,$:{id:kwrd0095},$$:[{#name:text,_:nitrogen-doped carbon nanotubes CNTs},{#name:keyword,$:{id:kwrd0105},$$:[{#name:text,_:carbon nanotubes CpG},{#name:keyword,$:{id:kwrd0115},$$:[{#name:text,_:oligodeoxynucleotides DTPA},{#name:keyword,$:{id:kwrd0125},$$:[{#name:text,_:diethylentriaminepentaacetic EBs},{#name:keyword,$:{id:kwrd0135},$$:[{#name:text,_:embryoid bodies EDC·HCl},{#name:keyword,$:{id:kwrd0145},$$:[{#name:text,_:1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride functionalized carbon nanotubes GO},{#name:keyword,$:{id:kwrd0165},$$:[{#name:text,_:graphene oxide HD},{#name:keyword,$:{id:kwrd0175},$$:[{#name:text,_:Huntington's disease hNSCs},{#name:keyword,$:{id:kwrd0185},$$:[{#name:text,_:human neural stem cells MCAO},{#name:keyword,$:{id:kwrd0195},$$:[{#name:text,_:middle cerebral artery occlusion METH},{#name:keyword,$:{id:kwrd0205},$$:[{#name:text,_:methamphetamine MPO},{#name:keyword,$:{id:kwrd0215},$$:[{#name:text,_:myeloperoxidase MWCNTs},{#name:keyword,$:{id:kwrd0225},$$:[{#name:text,_:multi-walled carbon nanotubes MWCNTTs},{#name:keyword,$:{id:kwrd0235},$$:[{#name:text,_:multi-walled nanotube towers ND},{#name:keyword,$:{id:kwrd0245},$$:[{#name:text,_:nanodiamond NHS},{#name:keyword,$:{id:kwrd0255},$$:[{#name:text,$$:[{#name:italic,_:N},{#name:__text__,_:-hydroxysuccinimide NR},{#name:keyword,$:{id:kwrd0265},$$:[{#name:text,_:nanorod NSCs},{#name:keyword,$:{id:kwrd0275},$$:[{#name:text,_:neural stem cells PBEC},{#name:keyword,$:{id:kwrd0285},$$:[{#name:text,_:porcine brain endothelial cells PCL},{#name:keyword,$:{id:kwrd0295},$$:[{#name:text,_:polycaprolactone PD},{#name:keyword,$:{id:kwrd0305},$$:[{#name:text,_:Parkinson's disease PEG},{#name:keyword,$:{id:kwrd0315},$$:[{#name:text,_:polyethylene-glycol PET},{#name:keyword,$:{id:kwrd0325},$$:[{#name:text,_:position emission tomography PMo11V},{#name:keyword,$:{id:kwrd0335},$$:[{#name:text,_:tetrabutylammonium salt of phosphovanadomolybdate POCs},{#name:keyword,$:{id:kwrd0345},$$:[{#name:text,_:polycyclic organic compounds PPy/SWCNT},{#name:keyword,$:{id:kwrd0355},$$:[{#name:text,_:polypyrrole/single-walled carbon nanotube RES},{#name:keyword,$:{id:kwrd0365},$$:[{#name:text,_:reticuloendothelial system siRNA},{#name:keyword,$:{id:kwrd0375},$$:[{#name:text,_:small interfering RNA SWCNTP},{#name:keyword,$:{id:kwrd0385},$$:[{#name:text,_:single-walled nanotube paper SWCNTs},{#name:keyword,$:{id:kwrd0395},$$:[{#name:text,_:single-walled carbon nanotubes TLR9},{#name:keyword,$:{id:kwrd0405},$$:[{#name:text,_:the toll-like receptor-9 TMZ},{#name:keyword,$:{id:kwrd0415},$$:[{#name:text,_:temozolomide |
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