Diagnostic usefulness of transbronchial lung cryobiopsy in two patients mildly affected with pulmonary lymphangioleiomyomatosis |
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| Affiliation: | 1. Department of Respiratory Medicine, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan;2. Department of Pathology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan;1. Department of Pharmacy Services, Medical University of South Carolina, Charleston, SC;2. Eshelman School of Pharmacy, University of North Carolina at Asheville, Asheville, NC;3. Division of Pulmonary Medicine, Cleveland Clinic, Cleveland, Ohio;4. Department of Medicine, Medical University of South Carolina (MUSC), Charleston, SC;5. Division of Pulmonary and Critical Care, Allergy and Sleep Medicine, MUSC, Charleston, SC;1. Department of Respiratory Medicine, Tokyo Women׳s Medical University, Tokyo, Japan;2. Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA;3. Tokyo Women׳s Medical University Institute for Integrated Medical Sciences, Tokyo, Japan;4. Department of Surgical Pathology, Tokyo Women׳s Medical University, Tokyo, Japan;5. Department of Medical Education, Tokyo Women׳s Medical University School of Medicine, Tokyo, Japan;6. Department of Thoracic Surgery, Tokyo Women׳s Medical University, Tokyo, Japan;1. Department of Respiratory Medicine, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8953, Japan;2. Department of Infectious Diseases, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8953, Japan;3. Department of Emergency and Critical Care Medicine, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8953, Japan;1. Servicio de Neumología, Departamento de Medicina, Hospital de la Santa Creu i Sant Pau, Universidad Autónoma de Barcelona, Barcelona, España;2. Servicio de Anestesiología, Hospital de la Santa Creu i Sant Pau, Universidad Autónoma de Barcelona, Barcelona, España |
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| Abstract: | ![]()
Transbronchial lung biopsy is a non-invasive technique used primarily for the pathological diagnosis of lymphangioleiomyomatosis (LAM). However, some cases, particularly those with early-stage lung lesions, are difficult to diagnose because of the specimen size and presence of artifacts. Herein, we present two cases of LAM with relatively mild cystic changes in the lungs and slight impairment seen in pulmonary function tests. Both patients were diagnosed pathologically through transbronchial lung cryobiopsy. These cases indicate that transbronchial lung cryobiopsy is a useful tool for diagnosing early-stage pulmonary LAM owing to its appropriate specimen size for detecting LAM cells and few crush artifacts. |
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| Keywords: | Lymphangioleiomyomatosis Transbronchial lung cryobiopsy Transbronchial lung biopsy Surgical lung biopsy Diagnosis LAM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" lymphangioleiomyomatosis TBLB" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" transbronchial lung biopsy TBLC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" transbronchial lung cryobiopsy SLB" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" surgical lung biopsy ILD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" interstitial lung disease CT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" computed tomography forced expiratory volume in 1 s PFT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" pulmonary function test diffusion capacity for carbon monoxide |
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