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The gut microbiome: an orchestrator of xenobiotic metabolism

Institution:	1. Department of Biochemistry, Microbiology, and Molecular Biology, the Pennsylvania State University, University Park, PA 16802, USA;2. Department of Veterinary and Biomedical Science, the Pennsylvania State University, University Park, PA 16802, USA

Abstract:

Keywords:	Gut microbiome Xenobiotic metabolism Absorption Gastrointestinal tract Pharmacokinetics Enterohepatic circulation Bioactivation 5-ASA"} {"#name":"keyword" "$":{"id":"kwrd0050"} "$$":[{"#name":"text" "_":"5-aminosalicylic acid 5-FU"} {"#name":"keyword" "$":{"id":"kwrd0060"} "$$":[{"#name":"text" "_":"5-fluorouracil AHR"} {"#name":"keyword" "$":{"id":"kwrd0070"} "$$":[{"#name":"text" "_":"aryl Hydrocarbon Receptor ALDH"} {"#name":"keyword" "$":{"id":"kwrd0080"} "$$":[{"#name":"text" "_":"aldehyde dehydrogenase BDE"} {"#name":"keyword" "$":{"id":"kwrd0090"} "$$":[{"#name":"text" "_":"bromodiphenyl ether BRV"} {"#name":"keyword" "$":{"id":"kwrd0100"} "$$":[{"#name":"text" "_":"brivudine BVU"} {"#name":"keyword" "$":{"id":"kwrd0110"} "$$":[{"#name":"text" "_":"bromovinyluracil CAR"} {"#name":"keyword" "$":{"id":"kwrd0120"} "$$":[{"#name":"text" "_":"constitutive androgen receptor cytochrome glycoside reductase CV"} {"#name":"keyword" "$":{"id":"kwrd0140"} "$$":[{"#name":"text" "_":"conventional CYP"} {"#name":"keyword" "$":{"id":"kwrd0150"} "$$":[{"#name":"text" "_":"cytochrome P450 ER"} {"#name":"keyword" "$":{"id":"kwrd0160"} "$$":[{"#name":"text" "_":"estrogen receptor FXR"} {"#name":"keyword" "$":{"id":"kwrd0170"} "$$":[{"#name":"text" "_":"farnesoid X receptor GF"} {"#name":"keyword" "$":{"id":"kwrd0180"} "$$":[{"#name":"text" "_":"germ-free GUDCA"} {"#name":"keyword" "$":{"id":"kwrd0190"} "$$":[{"#name":"text" "_":"glycoursodeoxycholic acid NSAID"} {"#name":"keyword" "$":{"id":"kwrd0200"} "$$":[{"#name":"text" "_":"non-steroidal anti-inflammatory drug PABA"} {"#name":"keyword" "$":{"id":"kwrd0210"} "$$":[{"#name":"text" "$$":[{"#name":"italic" "_":"p"} {"#name":"__text__" "_":"-aminobenzenesulphonamide PAH"} {"#name":"keyword" "$":{"id":"kwrd0220"} "$$":[{"#name":"text" "_":"polycyclic aromatic hydrocarbon PCB"} {"#name":"keyword" "$":{"id":"kwrd0230"} "$$":[{"#name":"text" "_":"polychlorinated biphenyl PD"} {"#name":"keyword" "$":{"id":"kwrd0240"} "$$":[{"#name":"text" "_":"Parkinson's disease PFOS"} {"#name":"keyword" "$":{"id":"kwrd0250"} "$$":[{"#name":"text" "_":"perfluorooctanesulfonic acid PXR"} {"#name":"keyword" "$":{"id":"kwrd0260"} "$$":[{"#name":"text" "_":"pregnane X receptor SCFA"} {"#name":"keyword" "$":{"id":"kwrd0270"} "$$":[{"#name":"text" "_":"short chain fatty acid SN-38G"} {"#name":"keyword" "$":{"id":"kwrd0280"} "$$":[{"#name":"text" "_":"SN-38 glucuronide SULT"} {"#name":"keyword" "$":{"id":"kwrd0290"} "$$":[{"#name":"text" "_":"sulfotransferase TCDF"} {"#name":"keyword" "$":{"id":"kwrd0300"} "$$":[{"#name":"text" "_":"2 3 7 8-tetrachlorodibenzofuran TUDCA"} {"#name":"keyword" "$":{"id":"kwrd0310"} "$$":[{"#name":"text" "_":"tauroursodeoxycholic acid UGT"} {"#name":"keyword" "$":{"id":"kwrd0320"} "$$":[{"#name":"text" "_":"uracil diphosphate-glucuronosyltransferase
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