老年高血压患者血压晨峰与内皮功能、心脏重构关系的研究

目的:通过检测动态血压、内皮细胞合成和分泌的血管活性物质及心脏结构,探讨老年高血压患者血压晨峰与内皮功能、心脏重构的关系。方法:将60例老年高血压患者按血压晨峰程度是否>50 mm Hg分为2组,A组血压晨峰≥50 mm Hg(33例),B组血压晨峰<50 mm Hg(27例)。所有受试者采用硝酸还原酶法,放射免疫法分别测定血清一氧化氮、内皮素含量,并进行超声心动图检查。结果:A组血清一氧化氮含量较B组低(P<0.05),血清内皮素含量较B组高(P<0.05);左心室肥厚发生率,左心房内径增大发生率较B组高(P<0.05)。结论:老年高血压患者血压晨峰程度与内皮功能损伤程度、心脏重构密切相关。

Study on the relationship of morning blood pressure surge with endothelial function and myocardial remodeling in senile patients with hypertension

Objective To study the relationship of morning blood pressure surge with endothelial function and myocardial remodeling by measuring ambulatory blood pressure,vasoactive substances from endothelial cells,and myocardial remodeling in senile patients with hypertension.Methods Sixty senile patients with hypertension were divided into 2 groups according to the degree of morning blood pressure surge.Thirty patients with morning blood pressure surge higher than 50 mm Hg were in group A and 27 patients with mornin...