252株耐药结核菌分析

目的：分析宝安区结核病耐药情况.方法：2003年门诊就诊的结核病例,用罗氏培养基进行痰菌培养,选择培养阳性进行药敏试验.结果：初始耐药率顺位依次为：链霉素（67.5%）、异烟肼（50.4%）、乙胺醇（32.9%）、利褐平（25.0%）.对1种2种3种和4种药物初始耐药率分别为48.0%、29.4%、3.6%、9.9%,获得耐药率为4.0%、3.2%、0%、2.0%,常住人口耐药率为21.4%,暂住人口为78.6%.在46例耐多药病列中,常住人口耐多药率为26.1%,暂住人口为73.9%,暂住人口明显多过常住人口.耐药率男女之间没有显著差别.宝安区暂住人口40岁以下的成年人是结控工作的主要对象.结论：初始耐药病例是宝安区主要耐药病例,是结核病防治的新问题.

ANALYSIS FOR 252 STRAIN OF RESISTANCE MYCOBACTERIUM TUBERCULOSIS.

Objective:To probe the resistance mycobacterium of circumstance in Baoan district.Methods:cultural examination by the L-J medium were applied to sputum of the clinic patients in 2003.Sensistility testing of anti-tuberculosis drugs was conducted for all isolated Colonies from pasitive sputum.Results:The initial drug resistance sequence of 252 strain were SM(67.5%),INH(50.4%),EMB(32.9%),RFP(25.0%).The resistance rate of one,two,three or four medicine were 48.0%,29.4%,3.6%,9.9% in the initial drug resistance respectively and these were 4.0%,3.2%,0%,2.0% in the acquired drug resistance respectively.In the 46 cases of MDR-TB,cases of the temporary household is more than the perpetual household.Resistance rate was 21.4% in the perpetual household and was 78.6% in the temporary household.It is not signifcantly different beween male and female.Conclusion:Major cases of initial drug resistance in resistance tuberculosis patients were temporary household in the Baoan district.That is a new problem of tubrculosis prevention and control.