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多价细菌疫苗预防原发性肾病综合征患儿医院感染的临床研究
引用本文:叶庆标 黄婷 李志辉 王影齐. 多价细菌疫苗预防原发性肾病综合征患儿医院感染的临床研究[J]. 实用全科医学, 2004, 2(2): 132-134
作者姓名:叶庆标 黄婷 李志辉 王影齐
作者单位:广东省深圳市罗湖区妇幼保健院儿科 518019(叶庆标,黄婷,李志辉),广东省深圳市罗湖区妇幼保健院儿科 518019(王影齐)
摘    要:目的 探讨多价细菌疫苗—兰菌净预防原发性肾病综合征 (PNS)患儿医院感染的疗效。方法 对 46例PNS患儿采用随机对照方法观察比较兰菌净治疗组和对照组的感染率、治疗前后T细胞亚群、免疫球蛋白及尿蛋白量下降程度的变化。结果治疗后 ,治疗组的医院感染率为 9.1% ,对照组为 3 7.5 % ,两组比较差异有显著意义 (P <0 .0 5 ) ;治疗组的T细胞亚群、免疫球蛋白等免疫指标比对照组有明显改善 ,CD3、CD4、IgG、IgA增高 (P <0 .0 1) ,CD8降低 ,CD4 CD8比值增高 (P <0 .0 5 ) ;而 2 4h尿蛋白量在治疗后有不同程度下降 ,但两组下降程度无差异 (P >0 .0 5 )。结论 兰菌净可明显降低PNS患儿的医院感染率。

关 键 词:多价细菌疫苗 原发性肾病综合征 医院感染 兰菌净 儿童 PNS 治疗
修稿时间:2003-08-29

The Clinical Research on Using Polyvalent Bacterial Vaccine to Prevent the Nosocomial Infection of Children With Primary Nephritic Syndrome
YE Qingbiao,HUANG Ting,LI Zhihui,et al.. The Clinical Research on Using Polyvalent Bacterial Vaccine to Prevent the Nosocomial Infection of Children With Primary Nephritic Syndrome[J]. Applied Journal Of General Practice, 2004, 2(2): 132-134
Authors:YE Qingbiao  HUANG Ting  LI Zhihui  et al.
Affiliation:YE Qingbiao,HUANG Ting,LI Zhihui,et al. Department of Pediatrics,Maternity and children Health Hospital in Luohu district of Shenzhen,Guangdong 518019
Abstract:Objectives To Observe the effect of oral polyvalent bacterial vaccine Lantigen B on preventing nosocomial infection of children with primary nephritic syndrome(PNS). Methods 46 PNS inpatients were divided into Lantigen B group (treated with Lantigen B) and control group randomly. The nosocomial infection rate, the decrease of albuminuria, the levels of T cell subset and immunoglobulin were observed in two groups. Results After treatment, the nosocomial infection rate of lantigen B group was 9.1%, and the rate of control group was 37.5%. The difference of nosocomial infection rate in two groups was significant (P<0.05). The differences of levels of T cell subset and immunoglobulin between two groups were significant. In Lantigen B group, the levels of CD3, CD4, IgG, IgA and the ratio of CD4/CD8 increased (P<0.01, or P<0.05), the number of CD8 decreased (P<0.05). The difference of the decrease on urine protein between two groups was insignificant (P>0.05). Conclusion Lantigen B can obviously reduce the nosocomial infection rate of PNS children.
Keywords:Nosocomial infection  Primary nephritic syndrome  Lantigen B
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