高氟对新生儿行为神经发育的影响

目的为了探讨孕期高氟摄入对新生儿行为神经发育的影响,评价氟对神经发育的毒性。方法随机抽取饮水型高氟地区黑龙江省肇州县出生的正常足月新生儿,根据孕妇当地饮水含氟量的不同分为高氟组及对照组,采用氟离子选择电极法测定孕妇产前尿氟,新生儿行为神经发育评分为效应指标。结果高氟组孕妇尿氟水平明显增高,高氟组与对照组新生儿行为神经发育总评分,主动肌张力、行为能力项中的非生物视定向反应、生物视听定向反应评分上差异有显著意义(P<0.05)。结论氟是一种神经发育毒物,孕母生活环境的高氟摄入对新生儿行为神经发育可产生不良影响。

Effects of high-fluoride on neonatal neurobehavioural development

Objective To research the effects of excessive fluoride intake during pregnancy on neonatal neurobehavioural development and to evaluate the neurodevelopment toxicity of fluoride. Methods Randomly selected 91 normal neonates delivered at the departments of obstetrics and gynecology in the five hospitals of Zhaozhou county Heilongjiang province from Dec 2002 to Jan 2003. They were divided into two groups-high-fluoride group and control group, according to the fluoride content in the drinking water of pregnant women living areas. The fluoride content in the urine of the pregnant women was determined, respectively with fluoride ion selective electrode method, and NBNA(neonatal behavioural neurological assessment) score as an effect indicator. Results The results showed that the urinary fluoride levels of maternal from the high-fluoride group were obviously higher than those of the control group. There were significant differences in NBNA total score and neonatal behavioural score between the endemic area group and the control group. There also were significant differences in nonbiological visual orientation reaction (NBVOR) and biological visual and auditory orientation reaction (BVAOR). Conclusions Fluoride is a neurodevelopment toxic. Excessive fluoride intake during pregnancy can cause adverse effects on neonatal neurobehavioural development.