原癌基因蛋白质C-erbB-2在乳腺良恶性病变中表达的意义

目的:检测原癌基因蛋白质C-erbB-2在乳腺良恶性病变中的表达及意义.方法:对111例乳腺良恶性病变的石蜡切片标本进行免疫组织化学染色.结果:乳腺良恶性病变中乳腺导管内乳头状瘤病的C-erbB-2阳性率为31.3%,与乳腺纤维腺病和纤维腺瘤比较差异有显著性(P<0.01),乳腺癌C-erbB-2的阳性率为74.3%,与良性病变比较差异有显著性(P<0.01);乳腺癌C-erbB-2表达与肿瘤大小和组织学分级呈正比(P<0.05),与激素受体(ER、PR)水平及5年生存期呈反比(P<0.05),与淋巴结是否转移无关.结论:C-erbB-2表达的乳腺导管内乳头状瘤病容易癌变,C-erbB-2过度表达的乳腺癌组织分化差、生存期短、预后不好.C-erbB-2 可作为判定乳腺导管内乳头状瘤病早期癌变及乳腺癌预后的有效指标.

Clinical significance of expression of oncoprotein C-erbB-2 in breast neoplasm diseases

Objective:To study on the expression of oncoprotein C erbB 2 in breast neoplasm diseases including benign and malignant diseases and its significance.Methods:The expression of C erbB 2 was determined in paraffin embedded specimens of breast diseases including benign and malignant tumours by immunohistochemistry.Results:Positive rate of C erbB 2 expression was 31.3% in breast intraductal papillomatosis,which was higher than those in other breast benign diseases ( P <0 01). The expression rate of C erbB 2 in breast cancer was 74.3%. There was a coordinated relationship between the expression of C erbB 2 and tumor size and both histological grade in breast cancer ( P <0 05) but inverse relationship between the expression of C erbB 2 and both level of estrogen receptor (ER), progestogen receptors (PR) and the survival duration for five years ( P <0 05). There was no any relationship between the expression of C erbB 2 and the metastases of lymph nodes.Conclusion:C erbB 2 expression may be considered as a efficient factor identifying the early canceration of the intraductal papillomatosis and evaluating the prognosis of breast cancer.