右美托咪啶在老年直肠癌患者根治术全麻诱导前的应用研究

为探讨老年直肠癌患者根治术全麻诱导前应用右美托咪啶（DEX）的效果，将2011年7～9月于全麻下行直肠癌根治术的60例老年患者随机分为观察组和对照组，每组30例。观察组于麻醉诱导前静脉泵注DEX0．4μg／kg，对照组静脉泵注等量生理盐水，对比两组患者静脉泵注DEX或生理盐水前（T0）、全麻诱导前（T1）、气管插管后1min（T2）及手术结束时（T3）的平均动脉压（MAP）和心率（HR），以及术中丙泊酚、苯磺顺阿曲库铵用量及七氟烷浓度。结果显示，L、L时两组MAP和HR比较差异均无统计学意义，P〉0．05；T1、T2时观察组MAP和HR均比对照组低，P〈0．05。观察组术中丙泊酚用量、七氟烷浓度明显小于对照组，P〈0．05。结果表明，老年患者行直肠癌根治术全麻诱导前静脉泵注DEX可减少麻醉药用量，降低麻醉药使用浓度，提高患者麻醉的安全性。

Application of Dexmedetomidine before Systemic Anesthesia Induction for Radical Surgery of Senile Rectal Carcinoma Patients

This study was to investigate the efficacy of Dexmedetomidine （DEX） used before systemic an- esthesia induction for radical surgery of senile rectal carcinoma patients. The 60 senile patients to be subjec- ted to radical surgery for their rectal carcinoma from July to Sept. , 2011 yr. were randomly divided into observation group and control group,30 cases for each one;before induction observation group received in- jection of DEX at 0.4μg/kg, while control group at same volume of normal saline by venous-pump, the fol- lowing items were detected and observed such as MAP（mean artery pressure） and HR（heart rate） at To （before injection by venous-pump）, T1 （before induction）, T2 （lmin after tracheal catheterization） and T3 （at the end of operation）,as well as intraoperative dosage of propofol and cis-atracurium,and the concen- tration of sevoflurane. As results,in MAP and HR at T0 and T1 there was no statistical differences between both groups（ P 〉0.05） ,but at T1 and T2 observation group were all lower than control group（ P 〉0.05） ; in the dosage of propofol and sevoflurane concentration observation group was all significantly less than control group（ P 〈0.05）. Results show that for radical surgery of senile rectal carcinoma patients before systemic anesthesia induction by venous-pump injecting DEX can reduce the dosage of anesthetics, decrease using concentration of anesthetics,so that enhance the patient＇s safety.