| 肾移植受者血清可溶性HLA—Ⅰ类抗原的动态监测 |
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| 引用本文： | Xu J,Cao Q,Wu D,Ma J,Yu L. 肾移植受者血清可溶性HLA—Ⅰ类抗原的动态监测[J]. 中华外科杂志, 1999, 37(11): 657-659 |
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| 作者姓名： | Xu J Cao Q Wu D Ma J Yu L |
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| 作者单位： | 第一军医大学南方医院肾移植科 |
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| 摘 要： | 目的 了解血清可溶性ＨＬＡ－Ⅰ类抗原（ｓＨＬＡ－Ⅰ）与肾移植受发生急性排斥反应及感染的关系。方法 应用酶联免疫法动态监测３６例肾移植受ｓＨＬＡ－Ⅰ水平。结果尿毒症组ｓＨＬＡ－Ⅰ水平为（２．９４±０．３４）μｇ／Ｌ,显高于正常对照组（０．７６±０．３３）μｇ／Ｌ（Ｐ〈０．０５）。移植后功能稳定组ｓＨＬＡ降至（０．６３±０．３１）μｇ／Ｌ,显低于尿毒症组（Ｐ〈０．０５）。ｓＨＬＡ－Ⅰ在发生排斥
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| 关 键 词： | 肾移植 移植物排斥 HLA－1类抗原 |
Dynamic monitoring of serum soluble HLA class I antigens in renal transplant recipients |
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| Xu J,Cao Q,Wu D,Ma J,Yu L. Dynamic monitoring of serum soluble HLA class I antigens in renal transplant recipients[J]. Chinese Journal of Surgery, 1999, 37(11): 657-659 |
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| Authors: | Xu J Cao Q Wu D Ma J Yu L |
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| Affiliation: | Department of Kidney Transplantation, Nanfang Hospital, First Military Medical University, Guangzhou 510515. |
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| Abstract: | OBJECTIVE: To investigate the relations between serum soluble HLA class I antigens (sHLA-I) and the period of acute rejection and infection in renal transplant recipients. METHODS: We measured the serum levels of sHLA-I in 36 renal transplant recipients with ELISA dynamically. RESULTS: The serum sHAL-I levels were higher in uremia patients than in normal controls [(2.94 +/- 0.34) microg/L vs. (0.76 +/- 0.33) microg/L, P < 0.05]. After renal transplantation, the serum sHLA-I levels decreased significantly in stable patients [(0.63 +/- 0.33) microg/L], but increased significantly 3 days before acute rejection and 5 or 7 days after infection. CONCLUSIONS: The serum sHLA-I levels can be used as a parameter for monitoring acute rejection and infection in renal transplantation. |
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