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大鼠全脑暂时性脑缺血模型的复制
引用本文:袁红花,张光毅. 大鼠全脑暂时性脑缺血模型的复制[J]. 实验动物与比较医学, 2002, 22(1): 51-52
作者姓名:袁红花  张光毅
作者单位:徐州医学院,徐州 221002
基金项目:上海市卫生局百人计划资助 ( 98BR0 38)
摘    要:大鼠全脑暂时性脑缺血模型系进行四动脉结扎(4-VO),其中两条推动脉(VA)进行电凝针灼烧成永久性血管闭塞,两条颈总动脉(CCA)用显微动脉夹暂时性的阻断血流至实验所需要的适当时间,该期间大鼠的全脑完全缺血,用脑电图(EEG)验证。然后松开动脉夹,让CCA重新流动,使大鼠的全脑再灌注(re-perfusion)。由于脑缺血会造成脑组织一定的损伤,而且再灌注还会使受损伤的程度进一步加深。本实验证明该模型的复制动物本身必须有较高的级别、较弱的体质。在缺血和再灌注过程中,由于DNA的损伤,一些转录因子和蛋白质的表达发生改变,因此可以依此来研究人类脑缺血的发病机制和治疗机理。

关 键 词:脑缺血 四动脉结扎 再灌注 大鼠模型 全脑暂时性脑缺血
文章编号:1004-8448(2002)01-0051-02
修稿时间:2001-10-25

Comparison of Cardiac Function in Different Animal Models with Cardiac Failure
ZHU Tongying,HUANG Guoying,GU Yong,LIN Shanyan. Comparison of Cardiac Function in Different Animal Models with Cardiac Failure[J]. Laboratory Animal and Comparative Medicine, 2002, 22(1): 51-52
Authors:ZHU Tongying  HUANG Guoying  GU Yong  LIN Shanyan
Abstract:Objective To compare the characteristic of cardiac function in two different congestive heart failure animal models.Methods To establish different congestive heart failure animal models with abdominal aortocaval shunts and ligature of the left coronary artery respectively was established in rats. The cardiac function test was with Doppler echocardiography.Results All the rats in both groups had developed cardiac hypertrophy.Ejection fraction (EF) of rats with aortocaval shunts decreased,but cardiac output (CO) and blood pressure (BP) in this group maintained normal.While EF,CO and mean artery pressure (MAP) all reduced significantly in ligation rats,IRT increased in this group.Conclusions Abdominal aortocaval shunts leads to high output cardiac failure.Cardiac failure resulted from ligation of coronary artery is low output,which is more severe.Doppler echocardiography provides a simple,reliable easy|follow|up way to test cardiac function in rat.;
Keywords:Rat  Cardiac failure animal model  Cardiac function
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