PLASMA FOLLISTATIN CONCENTRATIONS INCREASE FOLLOWING LIPOPOLYSACCHARIDE ADMINISTRATION IN SHEEP |
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| Authors: | Rudi Klein Iain J Clarke† Mark P Hedger† David M Robertson† |
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| Institution: | *Department of Anatomy and Physiology, Royal Melbourne Institute of Technology, Bundoora;†Prince Henry's Institute of Medical Research;†Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia |
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| Abstract: | 1. The effect of inflammation induced by lipopolysaccharide (LPS) injection on plasma follistatin (FS) concentrations was investigated. 2. Plasma FS and tumour necrosis factor-α concentrations increase following LPS administration in ewes. 3. The rise in FS is similar, but more sustained, to that previously observed after surgery. 4. These results indicate a possible functional link between FS, inflammation and the acute-phase response. |
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| Keywords: | activin follistatin lipopolysaccharide tumour necrosis factor-α |
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