| 雷帕霉素对小鼠葡萄糖代谢水平的影响 |
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| 引用本文： | 周迎生,王丽娟,刘波,颜迪恩,张福庄,袁仙仙.雷帕霉素对小鼠葡萄糖代谢水平的影响[J].实验动物与比较医学,2012(6):1-4. |
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| 作者姓名： | 周迎生 王丽娟 刘波 颜迪恩 张福庄 袁仙仙 |
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| 作者单位： | 首都医科大学附属北京安贞医院内分泌科,北京市心肺血管疾病研究所,北京 100029;卫生部北京医院,北京 100730;首都医科大学附属北京友谊医院,北京100050;首都医科大学附属北京安贞医院内分泌科,北京市心肺血管疾病研究所,北京 100029;首都医科大学附属北京安贞医院内分泌科,北京市心肺血管疾病研究所,北京 100029;首都医科大学附属北京安贞医院内分泌科,北京市心肺血管疾病研究所,北京 100029 |
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| 摘 要： | 目的探讨雷帕霉素对葡萄糖代谢水平影响的特点、机制。方法选择4周龄、雄性C57BL/6小鼠,高热量、高脂饮食喂养8周后为肥胖组(HF,n=18),普通饲料喂养为正常组(NC, n =18)。两组小鼠分别给予安慰剂(n=6)、腹腔注射雷帕霉素(2 mg/kg,隔日1次, n=6)、喂饮2.37%亮氨酸水 (n =6),2周后分别行灌胃葡萄糖耐量试验(glucose tolerance test, GTT)、胰岛素耐受性试验(insulin tolerance test, ITT)以及胰岛组织病理学检查。结果正常组小鼠腹腔注射雷帕霉素后葡萄糖负荷30min血糖水平显著升高(与安慰剂组比P=0.038,与亮氨酸组比P=0.035)。肥胖组小鼠腹腔注射雷帕霉素后空腹血糖水平显著高于安慰剂组(P=0.031),葡萄糖负荷30 min血糖显著高于安慰剂组(P=0.013)、亮氨酸组(P=0.041)。仅正常组小鼠胰岛素敏感性与安慰剂组相比显著降低(P=0.039)。雷帕霉素干预后腹腔脂肪量显著减少(正常组与安慰剂组比P <0.001,肥胖组与安慰剂组比P=0.013)。 结论雷帕霉素对哺乳动物糖代谢水平有显著影响,正常小鼠与机体胰岛素敏感性下降有关；肥胖小鼠与胰岛素分泌功能受损、胰岛素抵抗相关。
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| 关 键 词： | 雷帕霉素 血糖 胰岛素抵抗 |
Effects of rapamycin on glucose metabolism and insulin resistance in obese mice |
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| ZHOU Ying-sheng,WANG Li-juan,LIU Bo,YAN Di-en,ZHANG Fu-zhuang and YUAN Xian-xian.Effects of rapamycin on glucose metabolism and insulin resistance in obese mice[J].Laboratory Animal and Comparative Medicine,2012(6):1-4. |
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| Authors: | ZHOU Ying-sheng WANG Li-juan LIU Bo YAN Di-en ZHANG Fu-zhuang and YUAN Xian-xian |
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| Institution: | Department of Endocrinology & Metabolism, Capital Medical University affiliated Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Vascular Diseases, Beijing 100029, China;Beijing Hospital, Beijing 100730;Beijing Friendship Hospital,Capital Medical University, Beijing 100050;Department of Endocrinology & Metabolism, Capital Medical University affiliated Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Vascular Diseases, Beijing 100029, China;Department of Endocrinology & Metabolism, Capital Medical University affiliated Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Vascular Diseases, Beijing 100029, China;Department of Endocrinology & Metabolism, Capital Medical University affiliated Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Vascular Diseases, Beijing 100029, China |
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