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Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma
Authors:Yan Chen  Hai-Ning Chen  Kui Wang  Lu Zhang  Zhao Huang  Jiayang Liu  Zhe Zhang  Maochao Luo  Yunlong Lei  Yong Peng  Zong-Guang Zhou  Yuquan Wei  Canhua Huang
Institution:1. Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China;2. Department of Gastrointestinal Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China;3. Department of Biochemistry and Molecular Biology, and Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, PR China
Abstract:
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  • Keywords:Ketoconazole  Mitophagy  Apoptosis  HCC  Cancer  Cyclooxygenase-2  Sorafenib
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