| 补肾活血合剂对糖尿病阳痿大鼠阴茎平滑肌组织中Bcl-2 Bax和Caspase-3表达的影响 |
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| 引用本文： | 张国豪,方再军,黄青松. 补肾活血合剂对糖尿病阳痿大鼠阴茎平滑肌组织中Bcl-2 Bax和Caspase-3表达的影响[J]. 中华中医药学刊, 2011, 0(2): 324-327 |
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| 作者姓名： | 张国豪 方再军 黄青松 |
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| 作者单位： | 中国中医科学院广安门医院;贵州茅台酒厂职工医院;成都中医药大学附属医院; |
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| 基金项目： | 贵州省卫生厅中管局重点科研资助项目(黔中医2005-30) |
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| 摘 要： | 目的:观察补肾活血合剂对糖尿病阳痿(DMED)大鼠阴茎平滑肌组织中Bcl-2、Bax、Caspase-3表达的影响。方法:将实验小鼠用2%链脲佐菌素液(STZ)按60mg/kg,腹腔注射建立糖尿病模型,然后在每只糖尿病模型大鼠颈项处注射阿朴吗啡(AP0sigma公司)80μg/kg,录相记录阴茎勃起次数。筛选DMED模型,将造成DMED模型随机分为正常组、模型组、中药高、低剂量组、达美康组、达美康+安雄组。除正常组外,其余各组连续给药12周,然后处死测定阴茎平滑肌组织中Bcl-2,Bax,Caspase-3的表达情况。结果:补肾活血合剂对Bcl-2,Bax,Caspase-3有改善作用。结论:补肾活血合剂对糖尿病阳痿大鼠阴茎平滑肌组织中Bcl-2,Bax,Caspase-3有调控效果。
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| 关 键 词： | 补肾活血合剂 糖尿病 阳痿 Bcl-2 Bax Caspase-3 中医药 |
The effects of the Reinforcing Kidney and Activating Blood Recipe Affecting the Value of bc1-2,bax and caspase-3 in the Tissue of Corpus Cavernosum Smooth Muscle of DMED-Rats |
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| ZHANG Guo-hao,FANG Zai-jun,HUANG Qing-song. The effects of the Reinforcing Kidney and Activating Blood Recipe Affecting the Value of bc1-2,bax and caspase-3 in the Tissue of Corpus Cavernosum Smooth Muscle of DMED-Rats[J]. Chinese Archives of Traditional Chinese Medicine, 2011, 0(2): 324-327 |
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| Authors: | ZHANG Guo-hao FANG Zai-jun HUANG Qing-song |
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| Affiliation: | ZHANG Guo-hao1,FANG Zai-jun2,HUANG Qing-song3(1.Guang'anmen Hospital of China Academy of Chinese Medical Science,Beijing 100053,China,2.Hospital of Mao-Tai Chiew Factory in Guizhou Province,Renhuai 564501,Guizhou,3.Affiliated Hospital of Chengdu University of Chinese Medicine,Chengdu 610075,Sichuan,China) |
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| Abstract: | Objective: Observing the effects of reinforcing kidney and activating blood recipe affecting the value of bc1-2,bax and caspase-3 in the tissue of corpus cavernosum Smooth muscle of DMED-rats.Methods: An animal model of diabetes was induced by a single intravenous dose of streptozotocin(STZ,60mg/kg body weight) in Wistar rats.Recording the numbers of penile erection of each rat by camera after subcutaneous inject of apomorphine(80mg/kg).Screening the model of STZ-rats with erectile dysfunction and grouping ... |
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| Keywords: | reinforcing kidney and activating blood recipe diabetes mellitus erectile dysfunction bc1-2 bax caspase-3 Chinese Medicine |
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