黄连四物汤治疗早期糖尿病肾病的临床疗效观察及对血清AGEs水平的影响

目的:观察黄连四物汤配合西医治疗对早期糖尿病肾病的临床疗效,及对血清AGEs水平的影响。方法:42例患者在西医治疗的基础上给予黄连四物汤,1剂/日,分2次服。分别在治疗前、治疗第3周末、第6周末、第9周末、第12周末测定空腹血糖(FBG)、血肌酐(SCr)、尿微量白蛋白排泄率(AER),比较各时间点上述指标差异;在治疗前、后测定血甘油三酯(TG)、总胆固醇(TC)、糖化血红蛋白(HbA1C)水平及晚期糖基化终末产物(AGEs),比较治疗前、后差异。应用SPSS 13.0统计软件进行分析。结果:FBG在治疗第6周后下降显著(P<0.01);尿AER在治疗第6周后下降显著(P<0.01);SCr在治疗第9周后下降明显(P=0.033);治疗后HbA1C、TG、TC、AGEs水平均较治疗前明显下降(P<0.01)。结论:黄连四物汤配合西医治疗具有良好临床疗效,不仅能显著下调血糖及糖化血红蛋白,还能调节血脂,明显降低早期糖尿病患者尿AER;同时还降低血浆AGEs水平,这可能是其降低尿AER的机制之一。

Clinical Effect of Huangliansiwu Formula in Treating Early Diabetic Nephropathy and Influence on Serum AGEs

Objective:To observe the clinical effect of Huangliansiwu formula in treating early diabetic nephropathy combined with western medical therapy and its influence on serum serum advanced glycation end products(AGEs).Methods:42 patient were given the western treatment basically,and also given the Huangliansiwu liquid medicine twice a day.Tested the fasting blood-glucose(FBG),serum creatinine(SCr),urinary albumin excretion rate(UAER) before therapy and on the third,sixth,ninth,twelfth weekends.Compared the diff...