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Preliminary Evaluation of the Safety and Efficacy of Standard Intravenous Immunoglobulins in Pregnant Women with Primary Cytomegalovirus Infection |
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| Authors: | Ennio Polilli Giustino Parruti Francesca D'Arcangelo Elisa Tracanna Luigi Clerico Vincenzo Savini Francesco D'Antonio Maurizio Rosati Lamberto Manzoli Domenico D'Antonio Giovanni Nigro |
| Affiliation: | aMicrobiology and Virology Unit, General Hospital of Pescara, Pescara, Italy;bInfectious Disease Unit, General Hospital of Pescara, Pescara, Italy;cObstetrics and Gynaecology Unit, General Hospital of Pescara, Pescara, Italy;dDepartment of Epidemiology and Public Health, University of Chieti, Chieti, Italy;ePaediatric Unit, University and Hospital of L''Aquila, L''Aquila, Italy |
| Abstract: | Hyperimmune globulins were reported to prevent and treat fetal cytomegalovirus (CMV) infection during pregnancy. Here, we report that infusions of standard human intravenous immunoglobulin significantly increase CMV IgG titers and avidity indexes in pregnant women, paving the way to their use for passive transfer of maternal CMV humoral immunity to fetuses. Preliminary data on perinatal outcomes of the first 67 newborns are encouraging. |
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