感染诱发的脑梗死发作时的循环免疫复合物

目的 分析循环免疫复合物(CIC)在脑梗死发作时的变化及其与近期感染的关系。方法测定46例动脉硬化性脑梗死病例发病初期和恢复期及124例正常对照的CIC、补体Clq、C3,脑梗死组病例做发病初期和恢复期的先后比较,同时与正常对照测定值比较。结果 脑梗死组发病初期CIC测定值(16.47±12.46mg/dl),高于正常对照组(6.70±4.27mg/dl,P<0.01),井在恢复期下降,Clq发病初期(0.14±0.04g/L)低于恢复期(0.17±0.04g/L,P<0.05)并低于正常对照(0.20±0.04g/L),C3(1.16±0.06g/L)低于正常对照组(1.71±0.57g/L)且先后两期测定变化无差异。按有/无感染史分两组比较,有感染史组梗死初期CIC高于无感染史组并持续到恢复期,Clq测定值两组均偏低,并在恢复期回升明显,有感染史组C3高于无感染史组,回升不明显。CIC与梗死的最大直径和面积呈一定正相关。结论 CIC升高可能与感染有关,梗死初期CIC与脑梗死损伤程度呈一定正相关。

Circulating immune complex in cerebral infatction triggered by preceding infection

Objective To study the changes of circulating immune complexc (CIO level on cerebral infarction (CD and its relation to preceding infection. Methods CIC, Clq, C3 levels in 46 CI cases were tested including 37 cases of atherothrombolic brain infarction and 9 cases of lacunnar stroke after onset and convalescence and compared with that of 124 controls. Results The CIC levels in initial stage (16. 47 12. 46mg/dl), were higher than that of the controls (6.70 4. 27mg/dl,P<0. 01),and declined in convalescence. Clq levels of initial stage (0. 14 0. 04g/l)were lower than that of convalescence (0. 17 0. 04g/l,P<0. 05)and controls (0.20 0. 04g/l),C3 levels(1. 16 0. 06g/l) in initial stage showed the same change as Clq and no difference between initial stage and convalescence. The difference of CIC, Clq, C3 levels between two case subgroups with and without infection showed that CIC levels in initial stage in cases with infection were higher than that without infection and lasted to convalescence. Clq levels of both groups were low and apparently enhanced in convalescence. C3 levels in cases with infection were higher than that without infection and had not apparently rising. CIC levels correlated positively with the square and diameter of injury of CI. Conclusion There might have been a association between the enhance of CIC levels and the preceding infection,the CIC levels correlated positively with the degree of injury of CI.