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| L——精氨酸对缺氧大鼠肺动脉胶原含量的影响 | |
| 引用本文： | 马占敏 刘秀兰. L——精氨酸对缺氧大鼠肺动脉胶原含量的影响[J]. 实用心脑肺血管病杂志, 2000, 8(3): 135-137 |
| 作者姓名： | 马占敏 刘秀兰 |
| 作者单位： | [1]河南省郑州市妇幼保健院儿科 [2]河北省承德市中心医院儿科 |
| 摘 要： | 目的：研究缺氧时肺动脉胶原含量的变化Ｌ－精氨酸（Ｌ－Ａｒｇ）对其影响。方法将Ｗｉｓｔａｒ大鼠随机分为对照组，缺氧组和缺氧＋Ｌ－精氨酸组，采用兔组织化学方法测定各组大鼠肺内肺动脉Ⅰ型胶原的含量。结果缺氧时肺内大、中、小型肺动脉中Ⅰ型胶原表达与对照组比较明显增加（ｑ值分别为８．６０，１６．００，１３．１４，Ｐ均〈０．０１），而缺氧＋Ｌ－精氨酸组肺内大、中、小型肺动脉中Ⅰ型胶原表达与缺氧组相比明显降低（ |
| 关 键 词： | L－精氨酸 缺氧 胶原 肺动脉 |
Effect of L-arginine on collagen content of pulmonary arteries of rat during hypoxia |
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| Ma Zhanmin,Liu Xiulan,Du Junbao,et al.. Effect of L-arginine on collagen content of pulmonary arteries of rat during hypoxia[J]. Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease, 2000, 8(3): 135-137 | |
| Authors: | Ma Zhanmin Liu Xiulan Du Junbao et al. |
| Affiliation: | Ma Zhanmin,Liu Xiulan,Du Junbao,et al. Henan Zhengzhou Health Institutcon for Women and clinldren,Zhengzhou 450053 |
| Abstract: | Objective Changes of collagen content in pulmonary arteries induced by hypoxic and the effects of L-argi-nine on its content were investigated. Methods Wistar rats were randomly divided into control group, hypoxic group, hypoxic with L-arginine group. Collagen I content of pulmonary artery of each rat was evaluated using immunohistochemistry technique. Results Collagen I expression of large, median and small intrapul-monary arteries was significantly increasedin hypoxic rats as compared with that of normal control(q = 8. 60,16. 00,13. 14,respectively ; P < 0. 01). However, Collagen I expression of large, median and small intrapulmonary arteries was significantly decreased in hypoxic rats treated with L-arginine as compared with that of hypoxic rats(g = 6. 75; 14. 75,12. 36,respectively,P <0. 01). Conclusion L-arginine inhib-ited collagen expression of hypoxic pulmonary arteries. |
| Keywords: | L-arginine hypoxic pulmonary artery collagen |
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