| 颈动脉粥样硬化斑块内MCP-1表达的研究 |
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| 引用本文： | 李华,蒲传强,门保忠,周定标.颈动脉粥样硬化斑块内MCP-1表达的研究[J].中风与神经疾病杂志,2006,23(1):28-29,I0001. |
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| 作者姓名： | 李华 蒲传强 门保忠 周定标 |
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| 作者单位： | 1. 中国人民解放军总医院神经内科,北京,100853
2. 中国人民解放军总医院神经外科,北京,100853 |
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| 摘 要： | 目的观察颈动脉粥样硬化(AS)斑块内单核细胞趋化蛋白-1(MCP-1)的mRNA和抗原的表达情况。方法分别应用原位杂交和免疫组织化学法测定颈AS斑块中MCP-1mRNA和抗原表达。结果相对于正常动脉内膜,颈AS病变内膜MCP-1阳性细胞数明显增多(P<0.05)。其中颈AS严重病变肩区阳性细胞数最多,以单核-巨噬细胞为主。结论MCP-1与颈AS发生密切相关。
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| 关 键 词： | 颈动脉 动脉粥样硬化 单核细胞趋化蛋白-1 |
| 文章编号： | 1003-2754（2006）01-0028-02 |
| 收稿时间： | 2005-04-22 |
| 修稿时间： | 2005-04-22 |
Study on expression of MCP-1 in the carotid atherosclerotic plaques |
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| LI Hua ,PU Chuan-qiang,MEN Bao-zhong,et al..Study on expression of MCP-1 in the carotid atherosclerotic plaques[J].Journal of Apoplexy and Nervous Diseases,2006,23(1):28-29,I0001. |
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| Authors: | LI Hua PU Chuan-qiang MEN Bao-zhong |
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| Institution: | Department of Neurology,The General Hospital of PLA , Beijing 100853,China |
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| Abstract: | Objective To observe the mRNA and antigen expression of MCP-1 in the carotid atherosclerotic plaques. Methods Antigen and mRNA of MCP-1 was measured by immunocytochemistry and hybridization in situ respectively. Results MCP-1-positive cells in the intimas of the carotid AS plaques increased than those in the intimas of the normal arterial walls. There were most MCP-1-positive cells in the shoulder areas of the advanced lesions. The positive cells in the shoulder areas were mainly monocytes and macrophages. Conclusion MCP-1 is associated with the carotid atherosclerosis. |
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| Keywords: | Carotid artery Atherosclerosis Monocyte chemoattractant protein-1 |
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