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Susceptibility to human cancer: From the perspective of a pathologist
Authors:Haruhiko Sugimura
Affiliation:Department of Tumor Pathology, Hamamatsu University School of Medicine, Higashi‐ku, Hamamatsu, Japan
Abstract:
The etiologies of human cancer can only be discerned when the genetic clustering of cancer occurs within a family or when cancer occurs endemically in a particular environment. The possible approaches to solving the nature/nurture problem, especially for human carcinogenesis, posit a fascinating challenge for pathologists. This perspective review presents some examples of how clues to human cancer etiologies and/or susceptibilities reside in the realm of pathology practice. These examples using various omics techniques including adductomics, which I would like to highlight in this article, show that the currently available concepts and methods in human pathology can open a path toward the brave new world of a post‐genomic era of medicine for young pathologists, whether their original intention was toward the pursuit of diagnostic or investigative knowledge.
Keywords:adductome  adductomics  cancer susceptibility  exposome  gene‐environmental interaction  genetic polymorphism  molecular epidemiology
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