BCL2 antibodies targeted at different epitopes detect varying levels of protein expression and correlate with frequent gene amplification in diffuse large B-cell lymphoma |
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| Authors: | Samantha L. Kendrick,Lucas Redd,Andrea Muranyi,Leigh A. Henricksen,Stacey Stanislaw,Lynette M. Smith,Anamarija M. Perry,Kai Fu,Dennis D. Weisenburger,Andreas Rosenwald,German Ott,Randy D. Gascoyne,Elaine S. Jaffe,Elí as Campo,Jan Delabie,Rita M. Braziel,James R. Cook,Raymond R. Tubbs,Louis M. Staudt,Wing Chung Chan,Christian Steidl,Thomas M. Grogan,Lisa M. Rimsza |
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| Affiliation: | 1. Department of Pathology, University of Arizona, Tucson, AZ 85724;2. Ventana Medical Systems, Inc., Tucson, AZ 85755;3. Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE 68198;4. Department of Pathology, University of Manitoba, Winnipeg, MB, Canada R3A 1R9;5. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198;6. Department of Pathology, City of Hope Medical Center, Duarte, CA 91010;g Department of Pathology, University of Wuerzburg, Wuerzburg, Germany 97070;h Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch-Institu fur Klinische Pharmakologie (IKP), 70376 Stuttgart, Germany;i Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, BC, Canada V5Z 4E6;j Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892;k Department of Pathology, Hospital Clínic, Barcelona, Spain 08028;l Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway 0310;m Department of Clinical Pathology, Oregon Health & Science University, Portland, OR 97239;n Department of Molecular Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH 44195;o Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 |
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| Abstract: | |
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| Keywords: | Diffuse large B-cell lymphoma E17 and SP66 BCL2 antibodies Dual in situ hybridization (dual ISH) BCL2 phosphorylation BCL2 amplification and translocation |
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