|
|||||
|
|
| Association of interleukin-12 p40 gene 3＇-untranslated region polymorphism and outcome of HCV infection | |
| 引用本文： | Yin LM,Zhu WF,Wei L,Xu XY,Sun DG,Wang YB,Fan WM,Yu M,Tian XL,Wang QX,Gao Y,Zhuang H. Association of interleukin-12 p40 gene 3＇-untranslated region polymorphism and outcome of HCV infection[J]. World journal of gastroenterology : WJG, 2004, 10(16): 2330-2333. DOI: 10.3748/wjg.v10.i16.2330 |
| 作者姓名： | Yin LM Zhu WF Wei L Xu XY Sun DG Wang YB Fan WM Yu M Tian XL Wang QX Gao Y Zhuang H |
| 作者单位： | BeiiingDitanHospital,Beijing100730,China DepartmentofInfectiousDisease,FirstHospital,PekingUniversity,Beijing100034,China DepartmentofMicrobiology,SchoolofBasicMedicalSciences,PekingUmversity,Beijing100083,China DepartmentofMicrobiology,SchoolofBasicMedicalSciences,PekingUniversity,Beijing100083,China Gu＇anStationofDiseasePreventionandControl,Gu＇an102700,HebeiProvince,China HepatologyInstitute,People＇sHospital,PekingUniversity,Beijing100044,China |
| 基金项目： | 国家重点科技研究发展项目 |
| 摘 要： | AIM: To investigate the effect of interleukin-12 p40 gene (IL12E 3‘-untranslated region polymorphism on the outcome of HCV infection.METHODS: A total of 133 patients who had been infected with HCV for 12-25 (18.2±3.8) years, were enrolled in this study. Liver biochemical tests were performed with an automated analyzer and HCV RNA was detected by fluorogenic quantitative polymerase chain reaction. B-mode ultrasound was used for liver examination. Polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) was used for the detection of IL12B (1188A/C) polymorphism.RESULTS: Self-limited infection was associated with AC genotype (OR = 3.48; P = 0.001) and persistent infection was associated with AA genotype (OR = 0.34; P = 0.014)at site 1188 of IL12B. In patients with persistent HCV infection, no significant differences were found regarding the age, gender, duration of infection and biochemical characteristics (P>0.05). According to B-mode ultrasound imaging and clinical diagnosis, patients with persistent infection were divided into groups based on the severity of infection. No significant differences were found in the frequency of IL-12 genotype (1188A/C) between different groups (P>0.05).CONCLUSION: The polymorphism of II12B (1188A/C)appears to have some influence on the outcome of HCV infection. |
| 关 键 词： | 白细胞间介素-12 p40基因 3＇-未翻译 基因多态性 HCV 传染病 流行病 丙型肝炎 |
| 收稿时间： | 2004-01-15 |
Association of interleukin-12 p40 gene 3'-untranslated region polymorphism and outcome of HCV infection |
|
| Yin Li-Min,Zhu Wan-Fu,Wei Lai,Xu Xiao-Yuan,Sun De-Gui,Wang Yan-Bin,Fan Wen-Mei,Yu Min,Tian Xiu-Lan,Wang Qi-Xin,Gao Yan,Zhuang Hui. Association of interleukin-12 p40 gene 3'-untranslated region polymorphism and outcome of HCV infection[J]. World journal of gastroenterology : WJG, 2004, 10(16): 2330-2333. DOI: 10.3748/wjg.v10.i16.2330 | |
| Authors: | Yin Li-Min Zhu Wan-Fu Wei Lai Xu Xiao-Yuan Sun De-Gui Wang Yan-Bin Fan Wen-Mei Yu Min Tian Xiu-Lan Wang Qi-Xin Gao Yan Zhuang Hui |
| Affiliation: | 1. Department of Microbiology, School of Basic Medical Sciences, Peking University,Beijing 100083, China 2. Hepatology Institute, People's Hospital, Peking University, Beijing 100044, China 3. Department of Infectious Disease, First Hospital, Peking University, Beijing 100034, China 4. Gu'an Station of Disease Prevention and Control, Gu'an 102700, Hebei Province, China 5. Beijing Ditan Hospital, Beijing 100730, China |
| Abstract: | AIM: To investigate the effect of interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism on the outcome of HCV infection. METHODS: A total of 133 patients who had been infected with HCV for 12-25 (18.2+/-3.8) years, were enrolled in this study. Liver biochemical tests were performed with an automated analyzer and HCV RNA was detected by fluorogenic quantitative polymerase chain reaction. B-mode ultrasound was used for liver examination. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for the detection of IL12B (1188A/C) polymorphism. RESULTS: Self-limited infection was associated with AC genotype (OR = 3.48; P = 0.001) and persistent infection was associated with AA genotype (OR = 0.34; P = 0.014) at site 1188 of IL12B. In patients with persistent HCV infection, no significant differences were found regarding the age, gender, duration of infection and biochemical characteristics (P>0.05). According to B-mode ultrasound imaging and clinical diagnosis, patients with persistent infection were divided into groups based on the severity of infection. No significant differences were found in the frequency of IL-12 genotype (1188A/C) between different groups (P>0.05). CONCLUSION: The polymorphism of IL12B (1188A/C) appears to have some influence on the outcome of HCV infection. |
| Keywords: | |
| 本文献已被 维普 万方数据 PubMed 等数据库收录！ | |