| 脑出血患者外周血白细胞糖皮质激素受体及其效应指标的改变及意义 |
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| 引用本文： | 翟明,张云,赵瑛. 脑出血患者外周血白细胞糖皮质激素受体及其效应指标的改变及意义[J]. 标记免疫分析与临床, 1997, 0(3) |
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| 作者姓名： | 翟明 张云 赵瑛 |
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| 作者单位： | 云南省人民医院神经内科!昆明，650032(翟明)，云南省人民医院内分泌科!昆明，650032(张云)，上海长征医院神经内科!上海，200003(赵瑛) |
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| 摘 要： | 应用放射配体结合法，测定了56例脑出血患者外周血白细胞糖皮质激素受体（GR）的改变。结果发现脑出血组血浆皮质醇均明显升高，但白细胞GR随出血量的增多而降低越明显，并同时伴有氢化可的松（F）对中性多形核白细胞（PMN）趋化移动（ChtM）抑制率（FI）的降低。故测定GR有助于对病情及预后的判断。
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| 关 键 词： | 脑出血 皮质醇 白细胞 糖皮质激素受体 趋化移动 |
Change of Binding Capacity of Glucocorticoid Receptor in Leukocytes from Patients with Cerebral Hemorrhage and Its Clinical Implication |
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| Zhai Ming, Zhang Yun, Zhao Ying. Change of Binding Capacity of Glucocorticoid Receptor in Leukocytes from Patients with Cerebral Hemorrhage and Its Clinical Implication[J]. Labeled Immunoassays and Clinical Medicine, 1997, 0(3) |
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| Authors: | Zhai Ming Zhang Yun Zhao Ying |
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| Abstract: | The binding capacity of glucocorticoid receptor (GR) of peripherial leukocytes from 56 cases of cerebral hemorrhage was determined with radioligand binding assay. The results showed that plasma cortisol in cerebral hemorrhage patients was significantly increased, while the binding capacity of glucocorticoid receptor was significantly decreased and was inversely related to the quantity of hemorrhage. The fraction inhibition (FI) of chemotactic migration (ChtM) of neutrophils by hydrocortisone was also decreased. It is concluded that the seventy and prognosis of cerebral hemorrhage may be evaluated by measuring the binding capacity of GR. |
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| Keywords: | Hemorrhage cerebral Neutrophils Receptor glucocorticoid Hydrocortisone Chemotaxis |
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