上海市社区妇女子宫颈人乳头瘤病毒感染现况及危险因素研究

[目的]在社区人群中开展子宫颈人乳头瘤病毒(HPV)感染流行现况的检测,了解各年龄段妇女HPV感染率、感染人群分布,并分析HPV感染的影响因素,为女性宫颈癌的疫苗预防积累基础数据。[方法]在上海市某区,采用随机整群抽样,抽取两个社区常住妇女,年龄16~54岁。对有性生活史妇女采集宫颈口脱落细胞进行液基细胞学检查(LCT)和第二代杂交捕获技术(hc2)进行HPVDNA检测;对无性生活史的人群根据自己意愿进行会阴拭子采样,进行(hc2)HPVDNA检测。对LCT和HPVDNA检测均阳性者进行阴道镜下活检,进行病理诊断。并对研究对象问卷调查危险因素。[结果]有950名社区妇女接受了HPVDNA(hc2)检测,人群高危型HPV(HPV-H)阳性检出率为11.86%,低于全国水平(14.2%)。各年龄段30岁前感染率较低(8.93%、9.3%),31~35岁和41~45岁年龄段感染率较高,分别为15.13%和16.28%。结婚次数、用否避孕套、末次怀孕年龄是高危型HPV感染的影响因素。[结论]研究的社区人群高危型HPV感染率低于全国的平均水平。性生活史是HPV感染的重要影响因素。

THE PREVALENCE STUDY ON THE HUMAN PAPILLOMA VIRUSES(HPV) INFECTION AND THE RISK FACTORS OF THE COMMUNITY FEMALE POPULATION IN SHANGHAI

[Objective] To investigate the prevalence of human papilloma viruses (HPV) in community population and make a comprehension of the infectious rate, and analyse the risk factors of HPV infection, also accumulate basic data for primary prevention on cervical cancer. [Methods] A cross sectional study with random cluster sampling was given in a district in Shanghai. The objects were sampled in residential women aged between 16-54 in two communities. After consent, all eligible women were given an epidemical que...